Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening
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Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardiumStructural Insight into Unique Cardiac Myosin-binding Protein-C Motif: A PARTIALLY FOLDED DOMAINThe myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive mannerIn vivo left ventricular functional capacity is compromised in cMyBP-C null miceUnderstanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscleAblation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylationIn the thick of it: HCM-causing mutations in myosin binding proteins of the thick filamentC0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation.Zebrafish cardiac muscle thick filaments: isolation technique and three-dimensional structure.Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium.Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific mannerThe curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes.Comparative biomechanics of thick filaments and thin filaments with functional consequences for muscle contraction.Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.Myocardial contraction-relaxation couplingMeasuring myosin cross-bridge attachment time in activated muscle fibers using stochastic vs. sinusoidal length perturbation analysisCardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and functionMulti-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype.Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime.Cardiac myosin binding protein C insufficiency leads to early onset of mechanical dysfunction.Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-CCardiac Myosin-binding protein C modulates the tuning of the molecular motor in the heartCardiac myosin-binding protein C: A protein once at loose ends finds its regulatory groove.Slowing of contractile kinetics by myosin-binding protein C can be explained by its cooperative binding to the thin filament.In vivo cardiac myosin binding protein C gene transfer rescues myofilament contractile dysfunction in cardiac myosin binding protein C null miceInsights into length-dependent regulation of cardiac cross-bridge cycling kinetics in human myocardium.Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomereCardiac myosin binding protein-C is essential for thick-filament stability and flexural rigidityExpression patterns of cardiac myofilament proteins: genomic and protein analysis of surgical myectomy tissue from patients with obstructive hypertrophic cardiomyopathy.Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism.MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutationContractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo.Sarcomere control mechanisms and the dynamics of the cardiac cycle.Pressure-volume relation analysis of mouse ventricular function.Earning stripes: myosin binding protein-C interactions with actin.Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics.The genetic basis of hypertrophic cardiomyopathy in cats and humans.
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P2860
Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Role of cardiac myosin binding ...... entricular systolic stiffening
@ast
Role of cardiac myosin binding ...... entricular systolic stiffening
@en
Role of cardiac myosin binding ...... entricular systolic stiffening
@nl
type
label
Role of cardiac myosin binding ...... entricular systolic stiffening
@ast
Role of cardiac myosin binding ...... entricular systolic stiffening
@en
Role of cardiac myosin binding ...... entricular systolic stiffening
@nl
prefLabel
Role of cardiac myosin binding ...... entricular systolic stiffening
@ast
Role of cardiac myosin binding ...... entricular systolic stiffening
@en
Role of cardiac myosin binding ...... entricular systolic stiffening
@nl
P2093
P1433
P1476
Role of cardiac myosin binding ...... entricular systolic stiffening
@en
P2093
Bradley M Palmer
Christine E Seidman
David A Kass
David W Maughan
Diego F Belardi
Dimitrios Georgakopoulos
J G Seidman
Norman R Alpert
Richard L Moss
Samantha P Harris
P304
P356
10.1161/01.RES.0000126898.95550.31
P407
P577
2004-04-01T00:00:00Z