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Hypermutation in human cancer genomes: footprints and mechanisms

Hypermutation in human cancer genomes: footprints and mechanisms

http://www.wikidata.org/entity/Q28255066

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Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine CRISPR/Cas9 and cancer targets: future possibilities and present challenges The complexity of epigenetic diseases Genetic instability in the tumor microenvironment: a new look at an old neighbor Breaking bad: The mutagenic effect of DNA repair 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing.Repair of DNA Double-Strand Breaks in Heterochromatin Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes MosaicHunter: accurate detection of postzygotic single-nucleotide mosaicism through next-generation sequencing of unpaired, trio, and paired samples.APOBEC3B, a molecular driver of mutagenesis in human cancers.Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes The somatic autosomal mutation matrix in cancer genomes.APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.Chromothripsis and Kataegis Induced by Telomere Crisis Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics.An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers.APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions Tissue-specific tumorigenesis: context matters.Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.Epigenomic annotation of noncoding mutations identifies mutated pathways in primary liver cancer Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer.Clusters of Multiple Mutations: Incidence and Molecular Mechanisms APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.The journey of DNA repair Mutation pattern is an influential factor on functional mutation rates in cancer.Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli.High-Grade Neuroendocrine Colorectal Carcinomas: A Retrospective Study of 100 Patients Single-Molecule Force Spectroscopy Studies of APOBEC3A-Single-Stranded DNA Complexes.Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.When Genome Maintenance Goes Badly Awry.Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.

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Hypermutation in human cancer genomes: footprints and mechanisms

http://www.wikidata.org/entity/Q28255066

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2014 nî lūn-bûn

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2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Hypermutation in human cancer genomes: footprints and mechanisms

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Hypermutation in human cancer genomes: footprints and mechanisms

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Hypermutation in human cancer genomes: footprints and mechanisms

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Hypermutation in human cancer genomes: footprints and mechanisms

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Hypermutation in human cancer genomes: footprints and mechanisms

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Hypermutation in human cancer genomes: footprints and mechanisms

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Hypermutation in human cancer genomes: footprints and mechanisms

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Hypermutation in human cancer genomes: footprints and mechanisms

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Hypermutation in human cancer genomes: footprints and mechanisms

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Nature Reviews Cancer

P1476

Hypermutation in human cancer genomes: footprints and mechanisms

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Steven A Roberts

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P2860

Population stratification of a common APOBEC gene deletion polymorphism

What does our genome encode?

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma

A small-cell lung cancer genome with complex signatures of tobacco exposure

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Melanoma genome sequencing reveals frequent PREX2 mutations

Aristolochic acid-associated urothelial cancer in Taiwan

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Mutational processes molding the genomes of 21 breast cancers

A comprehensive catalogue of somatic mutations from a human cancer genome

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786-800

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872195

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10.1038/NRC3816

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12

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Dmitry A. Gordenin

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2014-12-01T00:00:00Z

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