Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
about
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomesSystems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypassDVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksRepeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin functionCheckpoint recovery in cells: how a molecular understanding can help in the fight against cancerProteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressThe F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stressHuman RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaksATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage responseHuman Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activitiesDNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc fingerThe Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpointControl of cell growth by the SCF and APC/C ubiquitin ligasesDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerUSP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinRecovery from the DNA Replication CheckpointDNA damage control: regulation and functions of checkpoint kinase 1Ubiquitylation, neddylation and the DNA damage responsePlk1- and beta-TrCP-dependent degradation of Bora controls mitotic progressionNovel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Roles of Chk1 in cell biology and cancer therapyPhospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage responseA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointRegulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neuronsNetwork architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway.CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptationAtaxin-3 promotes genome integrity by stabilizing Chk1.Regulatory functional territory of PLK-1 and their substrates beyond mitosis.DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation.The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage.Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidyIKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function.Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin.Cullins and cancer.Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.HERC2-USP20 axis regulates DNA damage checkpoint through Claspin.HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stabilityKu80 removal from DNA through double strand break-induced ubiquitylation.
P2860
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P2860
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@ast
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@en
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@nl
type
label
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@ast
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@en
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@nl
prefLabel
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@ast
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@en
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@nl
P50
P3181
P1433
P1476
Destruction of Claspin by SCFb ...... recovery from genotoxic stress
@en
P2093
Niels Mailand
P304
P3181
P356
10.1016/J.MOLCEL.2006.06.016
P407
P577
2006-08-04T00:00:00Z