The impact of single nucleotide polymorphisms on human aldehyde oxidase
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Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidaseOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsIdentification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificityIdentification and characterization of an antennae-specific aldehyde oxidase from the navel orangewormA framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologsPotential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbirdThe genetics of gout: towards personalised medicine?Human germline and pan-cancer variomes and their distinct functional profilesImpaired response or insufficient dosage? Examining the potential causes of "inadequate response" to allopurinol in the treatment of goutInterspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidaseFavipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted.Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase.Absolute quantification of aldehyde oxidase protein in human liver using liquid chromatography-tandem mass spectrometryStrategies for a comprehensive understanding of metabolism by aldehyde oxidase.Aldehyde oxidase and its importance in novel drug discovery: present and future challenges.Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.The role of drug metabolizing enzymes in clearance.Pharmacogenetic considerations in the treatment of gout.A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase.Structure and function of mammalian aldehyde oxidases.Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery.A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.Proteome-wide analysis of nonsynonymous single-nucleotide variations in active sites of human proteins.ecoAO: A Simple System for the Study of Human Aldehyde Oxidases Role in Drug Metabolism.Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids.A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry.AOX1 oxidises PXL to PDXateGenomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose.
P2860
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P2860
The impact of single nucleotide polymorphisms on human aldehyde oxidase
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@ast
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@en
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@nl
type
label
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@ast
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@en
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@nl
prefLabel
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@ast
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@en
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@nl
P2093
P2860
P921
P356
P1476
The impact of single nucleotide polymorphisms on human aldehyde oxidase
@en
P2093
Enrico Garattini
Jeffrey P Jones
Joshua F Alfaro
Mineko Terao
Tobias Hartmann
P2860
P304
P356
10.1124/DMD.111.043828
P407
P577
2012-05-01T00:00:00Z