Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics. - Wikidata - awgldk - TriplyDB

Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.

Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.

http://www.wikidata.org/entity/Q38151571

about

Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound.The application of engineered liver tissues for novel drug discovery.Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease.Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver.Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.

P2860

Q28077505-56F7D786-D80D-466C-B3BC-6F268A485A4A Q31002556-A39D6126-9687-423E-A83E-7C587A6BB05B Q38404573-9AEEB547-FFC1-4ACF-A572-B8E1635084ED Q39656279-7AF9BECE-4E99-43F0-A2F8-DCE5087A2458 Q40034799-B3FBA95A-AE7C-40DC-A503-EE2EEF99B48C Q41317951-23785F7F-0019-4E9E-8EE0-D65A7E1A2D7D Q46082485-96011596-D6BC-4DEF-A0EA-1CEB5C268A53 Q46453943-47156DAA-1EDE-44E2-9857-09B467DB3C9D Q48453320-7C1E6844-05EE-4B60-88D5-9D8F9ED70F96

P2860

Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.

http://www.wikidata.org/entity/Q38151571

description

article científic

@ca

article scientifique

@fr

articol științific

@ro

articolo scientifico

@it

artigo científico

@gl

artigo científico

@pt

artigo científico

@pt-br

artikel ilmiah

@id

artikull shkencor

@sq

artículo científico

@es

name

Chimeric mice transplanted wit ...... tabolism and pharmacokinetics.

@en

type

label

Chimeric mice transplanted wit ...... tabolism and pharmacokinetics.

@en

prefLabel

Chimeric mice transplanted wit ...... tabolism and pharmacokinetics.

@en

P1433

Q38151571-6113C1FE-5AE3-4E93-9536-17F464724F63

P1476

Q38151571-C17E0D86-E455-4350-BD06-0C3CF001770A

P2093

Q38151571-391DD459-6861-4E64-92CE-99B05F462CF9

Q38151571-39D39DA5-5E7E-4877-B17A-71F18E37043A

P2860

Q38151571-01F99387-2956-47C2-954D-9C033B74445D

Q38151571-03290ECF-DA35-479F-A644-A571BAD11371

Q38151571-09765FD0-CE6D-46F5-A79D-5E6CA7B86283

Q38151571-116A8BB4-B393-4106-9E9B-240FAE01ABE8

Q38151571-12284CD9-C988-4404-BA7F-41C5BE577727

Q38151571-12782148-C68A-4591-86B4-BB1F056CE076

Q38151571-135BBED7-2067-4D57-99ED-AF8E261944E4

Q38151571-13BFB879-AE13-47CE-9132-B16DB00AE155

Q38151571-1A6FD14C-1B38-4272-9FBF-4E2123225C8A

Q38151571-1F446507-50F6-4D89-99E4-DD4413B279EA

P304

Q38151571-B665E667-786D-47FA-81A4-D5F33C5054FF

P31

Q38151571-6B97EF4F-79C5-4456-8D5E-5B10E9B95CDE

P356

Q38151571-B3883317-0C32-4CD8-BBD3-F3B5A7BA6DAD

P433

Q38151571-B20BF298-38CD-487E-9FB6-CCF541778F2E

P478

Q38151571-B4366D66-7142-4477-8FEC-60AA5F3BBF26

P577

Q38151571-E012068A-3C53-45CD-A4D1-360F2FB81405

P5875

Q38151571-414A50D0-3309-4060-9718-3896A3A18577

P698

Q38151571-E4001934-9342-428B-B0DD-E18067FBBA8B

P356

P1433

Biopharmaceutics and Drug Disposition

P1476

Chimeric mice transplanted wit ...... tabolism and pharmacokinetics.

@en

P2093

Seigo Sanoh

http://www.w3.org/2001/XMLSchema#string

Shigeru Ohta

http://www.w3.org/2001/XMLSchema#string

P2860

The impact of single nucleotide polymorphisms on human aldehyde oxidase

Can the pharmaceutical industry reduce attrition rates?

Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance.

In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase.

Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes.

Prediction of hepatic clearance in human from in vitro data for successful drug development.

Exploratory population pharmacokinetics (e-PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research.

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration.

Hepatic hyperplasia associated with discordant xenogeneic parenchymal-nonparenchymal interactions in human hepatocyte-repopulated mice.

P304

71-86

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/BDD.1864

http://www.w3.org/2001/XMLSchema#string

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

35

http://www.w3.org/2001/XMLSchema#string

P577

2013-10-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

257648198

http://www.w3.org/2001/XMLSchema#string

P698

24114658

http://www.w3.org/2001/XMLSchema#string