Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.
about
Advances in Engineered Liver Models for Investigating Drug-Induced Liver InjuryAssessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound.The application of engineered liver tissues for novel drug discovery.Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease.Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver.Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.
P2860
Q28077505-56F7D786-D80D-466C-B3BC-6F268A485A4AQ31002556-A39D6126-9687-423E-A83E-7C587A6BB05BQ38404573-9AEEB547-FFC1-4ACF-A572-B8E1635084EDQ39656279-7AF9BECE-4E99-43F0-A2F8-DCE5087A2458Q40034799-B3FBA95A-AE7C-40DC-A503-EE2EEF99B48CQ41317951-23785F7F-0019-4E9E-8EE0-D65A7E1A2D7DQ46082485-96011596-D6BC-4DEF-A0EA-1CEB5C268A53Q46453943-47156DAA-1EDE-44E2-9857-09B467DB3C9DQ48453320-7C1E6844-05EE-4B60-88D5-9D8F9ED70F96
P2860
Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Chimeric mice transplanted wit ...... tabolism and pharmacokinetics.
@en
type
label
Chimeric mice transplanted wit ...... tabolism and pharmacokinetics.
@en
prefLabel
Chimeric mice transplanted wit ...... tabolism and pharmacokinetics.
@en
P2860
P356
P1476
Chimeric mice transplanted wit ...... tabolism and pharmacokinetics.
@en
P2093
Seigo Sanoh
Shigeru Ohta
P2860
P356
10.1002/BDD.1864
P577
2013-10-29T00:00:00Z