Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.
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Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal FunctionDysregulation and restoration of translational homeostasis in fragile X syndromeLearning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.The molecular basis of cognitive deficits in pervasive developmental disordersTargeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromesInhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and BackSTEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's diseaseInhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's diseasePhosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background.From FMRP function to potential therapies for fragile X syndrome.Modeling fragile X syndrome in the Fmr1 knockout mouseComparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome.Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.Effects of a social stimulus on gene expression in a mouse model of fragile X syndromeIncreasing our understanding of human cognition through the study of Fragile X Syndrome.Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disordersBehavioral and synaptic circuit features in a zebrafish model of fragile X syndrome.Fragile X mental retardation protein: from autism to neurodegenerative disease.STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and toleranceFragile X syndrome: causes, diagnosis, mechanisms, and therapeutics.BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity.Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase,The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity.Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders.The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: autism spectrum disorders and fragile x syndrome.Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models.A common STEP in the synaptic pathology of diverse neuropsychiatric disorders.Fragile X mental retardation protein and synaptic plasticityThe translation of translational control by FMRP: therapeutic targets for FXS.Progress toward treatments for synaptic defects in autism.Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation.Benzimidazole Scaffold as Anticancer Agent: Synthetic Approaches and Structure-Activity Relationship.Developing BACE-1 inhibitors for FXS.KCC2 expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.Tyrosine phosphatase STEP61 negatively regulates amyloid β-mediated ERK/CREB signaling pathways via α7 nicotinic acetylcholine receptors.Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity.
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P2860
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Genetic manipulation of STEP r ...... fragile X syndrome mouse model
@nl
Genetic manipulation of STEP r ...... ragile X syndrome mouse model.
@ast
Genetic manipulation of STEP r ...... ragile X syndrome mouse model.
@en
type
label
Genetic manipulation of STEP r ...... fragile X syndrome mouse model
@nl
Genetic manipulation of STEP r ...... ragile X syndrome mouse model.
@ast
Genetic manipulation of STEP r ...... ragile X syndrome mouse model.
@en
prefLabel
Genetic manipulation of STEP r ...... fragile X syndrome mouse model
@nl
Genetic manipulation of STEP r ...... ragile X syndrome mouse model.
@ast
Genetic manipulation of STEP r ...... ragile X syndrome mouse model.
@en
P2093
P2860
P3181
P1476
Genetic manipulation of STEP r ...... fragile X syndrome mouse model
@en
P2093
E D Wilson-Wallis
P J Lombroso
S M Goebel-Goody
S M Tagliatela
P2860
P304
P3181
P356
10.1111/J.1601-183X.2012.00781.X
P407
P577
2012-04-06T00:00:00Z