Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer
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Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domainsThe second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetaseActivity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domainsEvidence for 26 distinct acyl-coenzyme A synthetase genes in the human genomeMammalian long-chain acyl-CoA synthetasesO-GlcNAcylation: a bridge between glucose and cell differentiationBiochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase † , ‡Rational Redesign of the 4-Chlorobenzoate Binding Site of 4-Chlorobenzoate: Coenzyme A Ligase for Expanded Substrate Range † , ‡ , §Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase † ‡Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domainsMechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosisThe mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligaseThe 2.1 Å crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl-binding pocket for small branched acyl substratesStructure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore BiosynthesisGlobal Conformational Change Associated with the Two-step Reaction Catalyzed by Escherichia coli Lipoate-Protein Ligase AStructure of theD-alanylgriseoluteic acid biosynthetic protein EhpF, an atypical member of the ANL superfamily of adenylating enzymesBiochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophilaDefining a Structural and Kinetic Rationale for Paralogous Copies of Phenylacetate-CoA Ligases from the Cystic Fibrosis Pathogen Burkholderia cenocepacia J2315Structural Characterization and High-Throughput Screening of Inhibitors of PvdQ, an NTN Hydrolase Involved in Pyoverdine SynthesisStructures of Mycobacterium tuberculosis FadD10 Protein Reveal a New Type of Adenylate-forming EnzymeTopology of the yeast fatty acid transport protein Fat1p: mechanistic implications for functional domains on the cytosolic surface of the plasma membrane.Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosisMechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesisBioinformatic Analysis of Leishmania donovani Long-Chain Fatty Acid-CoA Ligase as a Novel Drug TargetContribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.A peroxisomal long-chain acyl-CoA synthetase from Glycine max involved in lipid degradation.Structure and function of enzymes involved in the biosynthesis of phenylpropanoidsGenome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles.Acyl-CoA synthesis, lipid metabolism and lipotoxicity.Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinementXanthomonas campestris RpfB is a fatty Acyl-CoA ligase required to counteract the thioesterase activity of the RpfF diffusible signal factor (DSF) synthase.Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorderA novel aromatic carboxylic acid inactivates luciferase by acylation of an enzymatically active regulatory lysine residue.Metabolic and tissue-specific regulation of acyl-CoA metabolism.Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol.Mutagenesis of rat acyl-CoA synthetase 4 indicates amino acids that contribute to fatty acid binding.Bacterial long chain fatty acid transport: gateway to a fatty acid-responsive signaling system.Mass spectrometry analysis and transcriptome sequencing reveal glowing squid crystal proteins are in the same superfamily as firefly luciferase.The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface.
P2860
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P2860
Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
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name
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@ast
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@en
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@nl
type
label
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@ast
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@en
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@nl
prefLabel
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@ast
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@en
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@nl
P2093
P2860
P50
P3181
P356
P1476
Structural basis of the substr ...... atty acyl-CoA synthetase dimer
@en
P2093
Keisuke Hamada
Masashi Miyano
Mitsuaki Sugahara
Noriko Nakagawa
Seiki Kuramitsu
Tetsuya Hori
Yasuhiro Arii
Yuko Hisanaga
P2860
P304
31717-31726
P3181
P356
10.1074/JBC.M400100200
P407
P577
2004-05-15T00:00:00Z