Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain
about
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycleRaf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulationNegative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1pA unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiationRegulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinasesGenomic structure of the human retinoblastoma-related Rb2/p130 geneDifferential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding proteinE2F activity is regulated by cell cycle-dependent changes in subcellular localizationE2F-4 switches from p130 to p107 and pRB in response to cell cycle reentryThe retinoblastoma family: twins or distant cousins?Tumor suppressors and cell-cycle proteins in lung cancerSubcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated musclep300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigenp130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activityE1A promotes association between p300 and pRB in multimeric complexes required for normal biological activityDual cyclin-binding domains are required for p107 to function as a kinase inhibitor.Fine scale mapping of the breast cancer 16q12 locus.Cumulative effect of phosphorylation of pRB on regulation of E2F activity.Mutational analysis of the conserved region 2 site of adenovirus E1A and its effect on binding to the retinoblastoma gene product: use of the "double-tagging" assayFunctional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression.In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130.The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patientsTargeting Rb inactivation in cancers by synthetic lethality.p107 is a suppressor of retinoblastoma development in pRb-deficient mice.Deletion of RB exons 24 and 25 causes low-penetrance retinoblastomaGenetic alterations of the retinoblastoma-related gene RB2/p130 identify different pathogenetic mechanisms in and among Burkitt's lymphoma subtypes.E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesisTranscription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein.Control of retinoblastoma protein-independent hematopoietic cell cycle by the pRB-related p130.Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma.Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer.Direct transcriptional repression by pRB and its reversal by specific cyclins.Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformationFunctional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteinsTranscriptional repression and growth suppression by the p107 pocket protein.Domains A and B in the Rb pocket interact to form a transcriptional repressor motif.The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.
P2860
Q21203547-B15067DD-7EB9-44F1-AAC3-A5A399A18172Q24522903-8FCD6442-4E9A-4424-A59E-303DF65C00C5Q24523723-5811AD71-81E7-4F2A-931F-5CC20A3ED270Q24540044-EEE074E8-D0BE-485D-8F38-2ED37AB03FB8Q24554228-B039ABF2-BF00-4C47-BF81-EF3965328693Q24568092-344ECA64-FEAD-4254-99C1-4ECBC0C5B9A0Q24602450-8A41573C-0D27-4FE0-A3A1-8F4E548A13A4Q24602495-8BF66762-15AD-4890-81F1-07939F384067Q24608934-4FA9FCB0-FF9E-4C0C-A7BC-452ABBAB187AQ24643965-21290FE0-D509-4072-9500-763CB5DB8F28Q24650515-FC5CDEB8-763B-4F2F-A054-F80549F3884BQ24792893-8B75376C-0635-4352-BA47-A482A7773BD4Q28392478-9EA1E600-43A7-47D4-8CD0-550690DF0A67Q28565236-27F58D23-9263-4C39-BD73-98EACEC9CCDEQ28565821-D8CCAD15-F49A-4D5C-81E8-AACE9A19C49DQ28647314-0256C03E-7D8A-4E3F-AA85-26FDB87F6FACQ30416673-D861AB6F-643A-43B1-ACE3-CA8DF52B9BEFQ33778594-87066777-C4EC-4E75-B9FA-04B5F6150839Q33878276-E2E65C73-33A2-428C-92FF-5EC762EE5A15Q33957868-8D71E3F1-9E0C-41BA-B0FA-A41B3ECA259CQ34352641-16B552F6-BC0B-4E25-8795-7748DE96A3E6Q34396889-BC16EC40-2D47-43E7-A23B-90DB6BDED211Q34430927-BFEEDD9A-8822-4257-9573-5C98344DE394Q34523801-0785EC17-834C-4DD2-9528-94BAC524798DQ35138543-86662B8E-3A38-4487-9B1E-88990C763376Q35201543-991BB20D-ACF1-40A0-A156-21380776ECC3Q35249353-DFA077D1-2AC8-41F5-96DB-1F3F6767B3BCQ35809785-1AA39CC7-6C69-413F-9D22-57B2E6D3F382Q35837977-16B07850-7B60-48F2-A041-218C8FB8CA42Q35853222-FBCEC67E-14F0-41E5-AEB3-76A10B3D8823Q36010329-F6860E6D-1A95-4AE6-9869-9CDF60F7CF6EQ36204411-424BDDAA-033F-49D5-A74E-881755F4ECC0Q36243414-08E5A763-71A3-4117-A67C-1965BF1F5594Q36322847-7EB46034-5348-4BAC-9F2A-2FC35FEB9BB0Q36551539-7ADD4577-FA77-4635-973E-146195D228C0Q36555544-9805421A-E1EC-4766-BC65-E9F5674EE11DQ36558284-6A1219D3-BDAE-46E9-A226-B9074F94BFA4Q36560772-0A669BAC-3A07-4BCA-84B8-B3DAD7C0A1C3Q36562117-FEB80BF8-10AB-462F-A570-5579AA60AC4CQ36564303-C261744B-E484-4B60-9591-C54361A71ADE
P2860
Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain
description
1993 nî lūn-bûn
@nan
1993 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Cloning of a new member of the ...... to the E1A transforming domain
@ast
Cloning of a new member of the ...... to the E1A transforming domain
@en
Cloning of a new member of the ...... to the E1A transforming domain
@nl
type
label
Cloning of a new member of the ...... to the E1A transforming domain
@ast
Cloning of a new member of the ...... to the E1A transforming domain
@en
Cloning of a new member of the ...... to the E1A transforming domain
@nl
prefLabel
Cloning of a new member of the ...... to the E1A transforming domain
@ast
Cloning of a new member of the ...... to the E1A transforming domain
@en
Cloning of a new member of the ...... to the E1A transforming domain
@nl
P2093
P3181
P1433
P1476
Cloning of a new member of the ...... to the E1A transforming domain
@en
P2093
P304
P3181
P407
P577
1993-09-01T00:00:00Z