Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis - Wikidata - awgldk - TriplyDB

Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis

Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis

http://www.wikidata.org/entity/Q28264978

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Citrullination of proteins: a common posttranslational modification pathway induced by different nanoparticles in vitro and in vivo Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2 Peptidylarginine Deiminases as Drug Targets in Neonatal Hypoxic-Ischemic Encephalopathy Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation Characterization and inactivation of an agmatine deiminase from Helicobacter pylori The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) i Born-Oppenheimer ab initio QM/MM molecular dynamics simulations of the hydrolysis reaction catalyzed by protein arginine deiminase 4.Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily.A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.A fluopol-ABPP HTS assay to identify PAD inhibitors.Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening.Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4 Ab initio QM/MM free-energy studies of arginine deiminase catalysis: the protonation state of the Cys nucleophile Kinetics of human peptidylarginine deiminase 2 (hPAD2)--reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains.Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor Kinase consensus sequences: a breeding ground for crosstalk.Histones: at the crossroads of peptide and protein chemistry.Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.Chemical biology of protein arginine modifications in epigenetic regulation Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.Mechanisms of catalysis and inhibition operative in the arginine deiminase from the human pathogen Giardia lamblia.Protein arginine deiminase 4: evidence for a reverse protonation mechanism.Activation of PAD4 in NET formation.Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage.Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps Chemical Proteomic Platform To Identify Citrullinated Proteins Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity.Protein Arginine Methylation and Citrullination in Epigenetic Regulation Protein arginine methyltransferases: from unicellular eukaryotes to humans Citrullination by peptidylarginine deiminase in rheumatoid arthritis.NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity Chemical mechanisms of histone lysine and arginine modifications Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential Listeria monocytogenes aguA1, but not aguA2, encodes a functional agmatine deiminase: biochemical characterization of its catalytic properties and roles in acid tolerance.Expression of peptidylarginine deiminase from Porphyromonas gingivalis in Escherichia coli: enzyme purification and characterization.

P2860

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P2860

Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis

http://www.wikidata.org/entity/Q28264978

description

2005 nî lūn-bûn

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2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2005 թվականի օգոստոսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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Kinetic characterization of pr ...... ession of rheumatoid arthritis

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Kinetic characterization of pr ...... ession of rheumatoid arthritis

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Kinetic characterization of pr ...... ession of rheumatoid arthritis

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Kinetic characterization of pr ...... ession of rheumatoid arthritis

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Kinetic characterization of pr ...... ession of rheumatoid arthritis

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Kinetic characterization of pr ...... ession of rheumatoid arthritis

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Kinetic characterization of pr ...... ession of rheumatoid arthritis

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Kinetic characterization of pr ...... ession of rheumatoid arthritis

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Kristen L Catchings

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Luo Yuan

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Mary C Glascock

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Michiyuki Yamada

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Monica Bhatia

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Nelroy G Jones

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Patricia L Kearney

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Paul R Thompson

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2658813

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10.1021/BI050292M

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