Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3
about
Cysteine-based regulation of the CUL3 adaptor protein Keap1Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potentialStructure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDOTrxR1 as a potent regulator of the Nrf2-Keap1 response systemDiscovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agentsPathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathwaysCACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsRedox-dependent anti-inflammatory signaling actions of unsaturated fatty acidsMechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid estersBasic principles and emerging concepts in the redox control of transcription factorsNrf2 regulates chronic lung inflammation and B-cell responses to nontypeable Haemophilus influenzaeThe Keap1-Nrf2 system in cancers: stress response and anabolic metabolismCytoprotection "gone astray": Nrf2 and its role in cancerThe antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compoundsProspective type 1 and type 2 disulfides of Keap1 protein.Transduction of redox signaling by electrophile-protein reactionsNADPH oxidase limits innate immune responses in the lungs in miceActivation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids.Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formationAn overview of mechanisms of redox signaling.Redox and electrophilic properties of vapor- and particle-phase components of ambient aerosolsThe ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.Electrophilic tuning of the chemoprotective natural product sulforaphane.Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.Modification of keap1 cysteine residues by sulforaphane.Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.Protein-selective capture to analyze electrophile adduction of hsp90 by 4-hydroxynonenal.Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer.Cell signalling by reactive lipid species: new concepts and molecular mechanisms.Regulation of innate immunity by NADPH oxidase.Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses.Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease preventionTrafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: implications for degradation of NRF2 in the nucleusIn vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathwayTargeted protein capture for analysis of electrophile-protein adducts.Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.
P2860
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P2860
Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@ast
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@en
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@nl
type
label
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@ast
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@en
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@nl
prefLabel
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@ast
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@en
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@nl
P2093
P356
P1476
Covalent modification at Cys15 ...... from the ubiquitin ligase CUL3
@en
P2093
Girish Rachakonda
Konjeti R Sekhar
Sheryl L Stamer
Ying Xiong
P304
P356
10.1021/TX700302S
P407
P577
2008-02-06T00:00:00Z