Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism. - Wikidata - awgldk - TriplyDB

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.

http://www.wikidata.org/entity/Q34800018

about

Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives Nitro-fatty acids: novel anti-inflammatory lipid mediators Inorganic nitrite supplementation for healthy arterial aging Roles nrf2 plays in myeloid cells and related disorders A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids Sulforaphane protects the heart from doxorubicin-induced toxicity Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase Phenotypic modulation of macrophages in response to plaque lipids.Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts.Induction of heme oxygenase I (HMOX1) by HPP-4382: a novel modulator of Bach1 activity.The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard.15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.Electrophilic fatty acids regulate matrix metalloproteinase activity and expression.15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids.Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies.Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes Formation and signaling actions of electrophilic lipids Nitrated Fatty Acids Reverse Cigarette Smoke-Induced Alveolar Macrophage Activation and Inhibit Protease Activity via Electrophilic S-Alkylation.Generation and esterification of electrophilic fatty acid nitroalkenes in triacylglycerides Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.Conjugated linoleic acid is a preferential substrate for fatty acid nitration.Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms.Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts.Electrophilic nitro-fatty acids prevent astrocyte-mediated toxicity to motor neurons in a cell model of familial amyotrophic lateral sclerosis via nuclear factor erythroid 2-related factor activation Influence of nutrition in PCB-induced vascular inflammation.In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans.Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14 -PGJ2.Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.Hormesis, cellular stress response, and redox homeostasis in autism spectrum disorders.An overview of the mechanisms and novel roles of Nrf2 in cardiovascular diseases.

P2860

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P2860

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.

http://www.wikidata.org/entity/Q34800018

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@ast

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@en

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@nl

type

label

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@ast

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@en

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@nl

prefLabel

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@ast

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@en

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@nl

P1433

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P2860

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P932

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P356

JBC.M110.190710

P1433

Journal of Biological Chemistry

P1476

Electrophilic nitro-fatty acid ...... ine 151-independent mechanism.

@en

P2093

Bruce A Freeman

http://www.w3.org/2001/XMLSchema#string

Francisco J Schopfer

http://www.w3.org/2001/XMLSchema#string

Gustavo Bonacci

http://www.w3.org/2001/XMLSchema#string

Hanna Leinonen

http://www.w3.org/2001/XMLSchema#string

Kit I Tong

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Steven R Woodcock

http://www.w3.org/2001/XMLSchema#string

P2860

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

P304

14019-14027

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P31

scholarly article

P356

10.1074/JBC.M110.190710

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P407

P433

16

http://www.w3.org/2001/XMLSchema#string

P478

286

http://www.w3.org/2001/XMLSchema#string

P50

Seppo Ylä-Herttuala

Carsten Carlberg

Emilia Kansanen

Suvi M Kuosmanen

Anna-Liisa Levonen

P577

2011-02-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

21357422

http://www.w3.org/2001/XMLSchema#string

P921

P932

3077602

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