5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation--an effect sensitive to NMDA receptor antagonism
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Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the ratNeuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's diseaseSerotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva)Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learningDown-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia.Mouse pharmacological models of cognitive disruption relevant to schizophrenia.Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia.5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine.Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy.E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.Blockade of dopamine D₃ but not D₂ receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment.Pro-cognitive action of CART is mediated via ERK in the hippocampus.Alzheimer's disease and age-related memory decline (preclinical)The hippocampo-prefrontal pathway: a possible therapeutic target for negative and cognitive symptoms of schizophreniaNADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology.Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus.5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease.The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats.Increased impulsivity and disrupted attention induced by repeated phencyclidine are not attenuated by chronic quetiapine treatment.Role of serotonin in Alzheimer's disease: a new therapeutic target?Acetylcholinesterase inhibitors: a patent review (2008 - present).The role of serotonin in memory: interactions with neurotransmitters and downstream signaling.Potential drug targets and treatment of schizophrenia.Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats.Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex.Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex.Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay.Ro 04-6790-induced cognitive enhancement: no effect in trace conditioning and novel object recognition procedures in adult male Wistar rats.A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis.Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse.The mGluR2/3 agonist LY379268 reverses post-weaning social isolation-induced recognition memory deficits in the rat.The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat.Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat.(+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics.Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats.
P2860
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P2860
5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation--an effect sensitive to NMDA receptor antagonism
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@ast
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@en
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@nl
type
label
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@ast
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@en
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@nl
prefLabel
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@ast
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@en
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@nl
P2093
P3181
P1433
P1476
5-HT6 receptor antagonists rev ...... ve to NMDA receptor antagonism
@en
P2093
A J Sleight
C A Marsden
I A Topham
M L Woolley
P304
P3181
P356
10.1016/J.NEUROPHARM.2004.03.012
P407
P577
2004-08-01T00:00:00Z