The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat.
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Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the ratGABA interneurons mediate the rapid antidepressant-like effects of scopolamine.5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's diseaseScopolamine administration modulates muscarinic, nicotinic and NMDA receptor systemsUsing the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia.E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.Increased expression of 5-HT₆ receptors in dorsolateral striatum decreases habitual lever pressing, but does not affect learning acquisition of simple operant tasks in rats.5-HT6 receptor agonism facilitates emotional learning.5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.Selective 5HT2A and 5HT6 receptor antagonists promote sleep in ratsThe effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats.The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment.Mechanism of acute tryptophan depletion: is it only serotonin?Role of serotonin in Alzheimer's disease: a new therapeutic target?Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models.5HT(6) receptor antagonists: a patent update. Part 1. Sulfonyl derivatives.Rationale for combining glutamatergic and cholinergic approaches in the symptomatic treatment of Alzheimer's disease.AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation.Task- and Treatment Length-Dependent Effects of Vortioxetine on Scopolamine-Induced Cognitive Dysfunction and Hippocampal Extracellular Acetylcholine in Rats.The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat.PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats.Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse.Memory impairments in humans after acute tryptophan depletion using a novel gelatin-based protein drink.Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram.5-HT6 receptor blockade differentially affects scopolamine-induced deficits of working memory, recognition memory and aversive learning in mice.
P2860
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P2860
The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
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2005年學術文章
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name
The selective 5-HT6 receptor a ...... memory deficiency in the rat.
@en
The selective 5-HT6 receptor a ...... memory deficiency in the rat.
@nl
type
label
The selective 5-HT6 receptor a ...... memory deficiency in the rat.
@en
The selective 5-HT6 receptor a ...... memory deficiency in the rat.
@nl
prefLabel
The selective 5-HT6 receptor a ...... memory deficiency in the rat.
@en
The selective 5-HT6 receptor a ...... memory deficiency in the rat.
@nl
P2093
P2860
P356
P1476
The selective 5-HT6 receptor a ...... memory deficiency in the rat.
@en
P2093
Arjan Blokland
Cindy K J Lieben
Petra van Nieuwenhuizen
Rudy Schreiber
P2860
P2888
P304
P356
10.1038/SJ.NPP.1300777
P407
P577
2005-12-01T00:00:00Z