about
Bacterial 2,4-dioxygenases: new members of the alpha/beta hydrolase-fold superfamily of enzymes functionally related to serine hydrolasesCrystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolutionComplement factor D, a novel serine proteaseIntrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triadCrystal structure of Helicobacter pylori formamidase AmiF reveals a cysteine-glutamate-lysine catalytic triadThe structure of PhaZ7 at atomic (1.2 Å) resolution reveals details of the active site and suggests a substrate-binding modeStructure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASEThe catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease actionOrigin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase: EFFECT OF THE BASICITY OF AN ACTIVE SITE HIS RESIDUEConstruction of a bisaquo heme enzyme and binding by exogenous ligandsStructure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignmentAt the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bondsEnzyme surface rigidity tunes the temperature dependence of catalytic ratesStructural basis of substrate specificity in the serine proteasesRecent developments in inhibiting cysteine and serine proteases.Protein structure and dynamics in nonaqueous solvents: insights from molecular dynamics simulation studies.Sequence Conservation, Radial Distance and Packing Density in Spherical Viral Capsids.The picornaviral 3C proteinases: cysteine nucleophiles in serine proteinase folds.Experimental pK(a) values of buried residues: analysis with continuum methods and role of water penetrationA study of the stabilization of tetrahedral adducts by trypsin and delta-chymotrypsin.Vibrational Stark Effects of Carbonyl Probes Applied to Reinterpret IR and Raman Data for Enzyme Inhibitors in Terms of Electric Fields at the Active SiteActive-site motions and polarity enhance catalytic turnover of hydrated subtilisin dissolved in organic solvents.Modeling of solvent-dependent conformational transitions in Burkholderia cepacia lipase.Regulation of enzymatic activity: one possible role of dietary boron in higher animals and humans.DNA duplex stability: the role of preorganized electrostatics.Validating computer simulations of enantioselective catalysis; reproducing the large steric and entropic contributions in Candida Antarctica lipase BPolarizable atomic multipole x-ray refinement: hydration geometry and application to macromoleculesGrand canonical ensemble Monte Carlo simulation of the dCpG/proflavine crystal hydrate.Catalytic reaction mechanism of acetylcholinesterase determined by Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.Functional characteristics of the oxyanion hole in human acetylcholinesterase.Diapause in the mosquito Culex pipiens evokes a metabolic switch from blood feeding to sugar gluttonyAnalysis of the conformational stability and activity of Candida antarctica lipase B in organic solvents: insight from molecular dynamics and quantum mechanics/simulations.On catalytic preorganization in oxyanion holes: highlighting the problems with the gas-phase modeling of oxyanion holes and illustrating the need for complete enzyme models.Consequences of breaking the Asp-His hydrogen bond of the catalytic triad: effects on the structure and dynamics of the serine esterase cutinase.Hydration of enzyme in nonaqueous media is consistent with solvent dependence of its activity.Stereoselective esterase from Pseudomonas putida IFO12996 reveals alpha/beta hydrolase folds for D-beta-acetylthioisobutyric acid synthesis.Enzymes work by solvation substitution rather than by desolvation.What are the dielectric "constants" of proteins and how to validate electrostatic models?Computational approaches to shed light on molecular mechanisms in biological processes
P2860
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P2860
description
1989 nî lūn-bûn
@nan
1989 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
How do serine proteases really work?
@ast
How do serine proteases really work?
@en
How do serine proteases really work?
@nl
type
label
How do serine proteases really work?
@ast
How do serine proteases really work?
@en
How do serine proteases really work?
@nl
prefLabel
How do serine proteases really work?
@ast
How do serine proteases really work?
@en
How do serine proteases really work?
@nl
P2093
P356
P1433
P1476
How do serine proteases really work?
@en
P2093
G Naray-Szabo
P304
P356
10.1021/BI00435A001
P407
P577
1989-05-02T00:00:00Z