Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
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Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitroProteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysinesCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepDual functions of Insig proteins in cholesterol homeostasisInsig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienolsSchoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteinsControl of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductaseIdentification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesisThe prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductaseForward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis.Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the Fras-1-related extracellular matrix protein (FREM2) gene.The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperonesLipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and GolgiAlpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II.Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cellsInsig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cellsRegulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranesIntramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.Regulation of cholesterol and fatty acid synthesis.Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation.Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.Degradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent.UbiA prenyltransferase domain-containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids.Manipulating Cholesterol Status Within Cells.Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells.
P2860
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P2860
Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
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2004 nî lūn-bûn
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2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
@zh-hant
2004年論文
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2004年論文
@zh-mo
2004年論文
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2004年论文
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name
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@ast
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@en
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@nl
type
label
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@ast
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@en
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@nl
prefLabel
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@ast
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@en
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@nl
P2093
P2860
P356
P1476
Isolation of mutant cells lack ...... lglutaryl-coenzyme A reductase
@en
P2093
Navdar Sever
Peter C W Lee
Robert B Rawson
Russell A Debose-Boyd
P2860
P304
43136-43147
P356
10.1074/JBC.M406406200
P407
P577
2004-07-07T00:00:00Z