Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
about
Leupaxin negatively regulates B cell receptor signalingSustained activation of Lyn tyrosine kinase in vivo leads to autoimmunityCD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium fluxSHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substratesThe inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activityCD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and NckThe Src kinase Lyn is a negative regulator of mast cell proliferationCarabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunityThe SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells.Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth.Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell toleranceA balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levelsRequirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient miceMyeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.BANK1 and BLK act through phospholipase C gamma 2 in B-cell signalingA single amino acid change in inhibitory killer cell Ig-like receptor results in constitutive receptor self-association and phosphorylation.CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cellsRole of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation.A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.A computational model for early events in B cell antigen receptor signaling: analysis of the roles of Lyn and Fyn.Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy.Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptorsDeficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies.Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc gamma RII-mediated B cell suppression.The molecular mechanism of B cell activation by toll-like receptor protein RP-105Multiple paths to loss of anergy and gain of autoimmunity.FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.Syk and pTyr'd: Signaling through the B cell antigen receptorGenetic associations of LYN with systemic lupus erythematosus.CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.Receptor crosstalk: reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontinMultiple roles of Lyn kinase in myeloid cell signaling and function.B cell-specific loss of Lyn kinase leads to autoimmunityPhosphorothioate-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for Toll-like receptor 9 in receptor revision.A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells.
P2860
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P2860
Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@ast
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@en
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@nl
type
label
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@ast
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@en
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@nl
prefLabel
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@ast
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@en
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@nl
P2093
P1433
P1476
Defective negative regulation ...... in Lyn-deficient B lymphocytes
@en
P2093
A L DeFranco
C A Lowell
P304
P356
10.1016/S0960-9822(98)70223-4
P407
P577
1998-05-07T00:00:00Z