B cell-specific loss of Lyn kinase leads to autoimmunity - Wikidata - awgldk - TriplyDB

B cell-specific loss of Lyn kinase leads to autoimmunity

B cell-specific loss of Lyn kinase leads to autoimmunity

http://www.wikidata.org/entity/Q37509056

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Targeting B-cell receptor signaling kinases in chronic lymphocytic leukemia: the promise of entospletinib B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production Mechanisms of autoantibody production in systemic lupus erythematosus The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway.Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development.A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels Altered B cell signalling in autoimmunity.Getting Syk: spleen tyrosine kinase as a therapeutic target.B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.Innate immune programing by endotoxin and its pathological consequences Animal Models of Interferon Signature Positive Lupus.Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus.Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels.Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells.B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.B Cells, Antibodies, and More.Infectivity and insertional mutagenesis of endogenous retrovirus in autoimmune NZB and B/W mice.Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.The Brain Proteome of the Ubiquitin Ligase Peli1 Knock-Out Mouse during Experimental Autoimmune Encephalomyelitis LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis.Role of Calcium Signaling in B Cell Activation and Biology.Anti-cardiac troponin antibodies in clinical human disease: a systematic review.B cells biology in systemic lupus erythematosus-from bench to bedside.TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells.Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.The multiple pathways to autoimmunity.Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases.The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases.Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM.Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity.Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul.Autoantibodies in SLE: Specificities, Isotypes and Receptors Ligand Recognition Determines the Role of Inhibitory B Cell Co-receptors in the Regulation of B Cell Homeostasis and Autoimmunity

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B cell-specific loss of Lyn kinase leads to autoimmunity

http://www.wikidata.org/entity/Q37509056

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 December 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

B cell-specific loss of Lyn kinase leads to autoimmunity

@en

B cell-specific loss of Lyn kinase leads to autoimmunity.

@nl

type

label

B cell-specific loss of Lyn kinase leads to autoimmunity

@en

B cell-specific loss of Lyn kinase leads to autoimmunity.

@nl

prefLabel

B cell-specific loss of Lyn kinase leads to autoimmunity

@en

B cell-specific loss of Lyn kinase leads to autoimmunity.

@nl

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JIMMUNOL.1301979

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Journal of Immunology

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B cell-specific loss of Lyn kinase leads to autoimmunity

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Anthony L DeFranco

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Chrystelle Lamagna

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Clifford A Lowell

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Yongmei Hu

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P2860

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

The role of dendritic cells in autoimmunity

Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance

Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms

TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

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scholarly article

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10.4049/JIMMUNOL.1301979

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