MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90 - Wikidata - awgldk - TriplyDB

MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90

MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90

http://www.wikidata.org/entity/Q28271920

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MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition Mucins in cancer: function, prognosis and therapy Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.Mucin 1 C-terminal subunit oncoprotein is a target for small-molecule inhibitors.MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression.Protein mislocalization: mechanisms, functions and clinical applications in cancer.Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation.EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1.Altered Mucins (MUC) trafficking in benign and malignant conditions.MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization.The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death.MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation.Mucin-interacting proteins: from function to therapeutics.Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein.Functional targeting of the MUC1 oncogene in human cancers MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.Post-translational regulation of signaling mucins.Novel monoclonal antibodies against the proximal (carboxy-terminal) portions of MUC16.Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.MUC1 oncoprotein regulates Bcr-Abl stability and pathogenesis in chronic myelogenous leukemia cells MUC1 is a substrate for gamma-secretase Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways The intracellular domain of cell adhesion molecule 1 is present in emphysematous lungs and induces lung epithelial cell apoptosis The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function.Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis MUC1 drives c-Met-dependent migration and scattering.Inhibition of the MUC1-C oncoprotein is synergistic with cytotoxic agents in the treatment of breast cancer cells.Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches.MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8.Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer.MUC1 mucin: a peacemaker in the lung.

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P2860

MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90

http://www.wikidata.org/entity/Q28271920

description

2005 nî lūn-bûn

@nan

2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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type

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MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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prefLabel

MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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MUC1 oncoprotein is targeted t ...... the molecular chaperone HSP90

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P2860

Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum

Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin

The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix.

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin

DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7

Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling

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1

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