A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition
about
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinIdas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionGeminin regulates neuronal differentiation by antagonizing Brg1 activityRegulation of replication licensing by acetyltransferase Hbo1.Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damagePreventing re-replication of chromosomal DNA.Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replicationFunctional domains of the Xenopus replication licensing factor Cdt1Non-transcriptional interactions of Hox proteins: inventory, facts, and future directionsGenomic instability in cancer.Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensingStructural basis for homeodomain recognition by the cell-cycle regulator GemininMcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil DomainThe Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication LicensingGEMC1 is a TopBP1-interacting protein required for chromosomal DNA replicationFamily-specific Kinesin Structures Reveal Neck-linker Length Based on Initiation of the Coiled-coil.Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirusA Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.An inactive geminin mutant that binds cdt1Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating GemininThe Expression and Prognostic Roles of MCMs in Pancreatic Cancer.Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertilityCell cycle regulation of DNA replication.Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.NF-kappaB and Snail1a coordinate the cell cycle with gastrulationGeminin is partially localized to the centrosome and plays a role in proper centrosome duplication.Transcription of the Geminin gene is regulated by a negative-feedback loop.FUCCI sensors: powerful new tools for analysis of cell proliferation.Two Geminin homologs regulate DNA replication in silkworm, Bombyx mori.Mechanisms and regulation of DNA replication initiation in eukaryotes.Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase.Geminin cleavage during apoptosis by caspase-3 alters its binding ability to the SWI/SNF subunit Brahma.The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteinsGEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication.Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis.
P2860
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P2860
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@ast
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@en
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@nl
type
label
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@ast
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@en
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@nl
prefLabel
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@ast
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@en
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@nl
P2093
P50
P3181
P1433
P1476
A dimerized coiled-coil domain ...... dt1 for replication inhibition
@en
P2093
David Takeda
Howard Robinson
Kunchithapadam Swaminathan
Sally Kornbluth
Sandeep Saxena
Takeshi Senga
P304
P3181
P356
10.1016/J.MOLCEL.2004.06.045
P407
P577
2004-07-23T00:00:00Z