Functional domains of the Xenopus replication licensing factor Cdt1 - Wikidata - awgldk - TriplyDB

Functional domains of the Xenopus replication licensing factor Cdt1

Functional domains of the Xenopus replication licensing factor Cdt1

http://www.wikidata.org/entity/Q24794160

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Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6 Prevention of DNA re-replication in eukaryotic cells Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability Helicase loading at chromosomal origins of replication Structural insights into the Cdt1-mediated MCM2-7 chromatin loading.Geminin inhibits a late step in the formation of human pre-replicative complexes.Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template.A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity.Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos.Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.Analysis of re-replication from deregulated origin licensing by DNA fiber spreading Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification.FUCCI sensors: powerful new tools for analysis of cell proliferation.Mechanisms and regulation of DNA replication initiation in eukaryotes.Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.Xenopus Mcm10 is a CDK-substrate required for replication fork stability.Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase.Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase.The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2 Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels.Geminin prevents rereplication during xenopus development.Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.Inter-origin cooperativity of geminin action establishes an all-or-none switch for replication origin licensing.Development of stapled helical peptides to perturb the Cdt1-Mcm6 interaction.Human Cdt1 lacking the evolutionarily conserved region that interacts with MCM2-7 is capable of inducing re-replication.Role of geminin: from normal control of DNA replication to cancer formation and progression?

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Functional domains of the Xenopus replication licensing factor Cdt1

http://www.wikidata.org/entity/Q24794160

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Functional domains of the Xenopus replication licensing factor Cdt1

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Functional domains of the Xenopus replication licensing factor Cdt1

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Functional domains of the Xenopus replication licensing factor Cdt1

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Functional domains of the Xenopus replication licensing factor Cdt1

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Functional domains of the Xenopus replication licensing factor Cdt1

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Functional domains of the Xenopus replication licensing factor Cdt1

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Functional domains of the Xenopus replication licensing factor Cdt1

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Functional domains of the Xenopus replication licensing factor Cdt1

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Nucleic Acids Research

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Functional domains of the Xenopus replication licensing factor Cdt1

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Anatoliy Li

http://www.w3.org/2001/XMLSchema#string

Andrew Ferenbach

http://www.w3.org/2001/XMLSchema#string

Marta Brito-Martins

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P2860

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

Self-assembling protein microarrays

The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells

Geminin, an inhibitor of DNA replication, is degraded during mitosis

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts

Loss of Geminin induces rereplication in the presence of functional p53

Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication

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316-324

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4758777

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10.1093/NAR/GKI176

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1

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33

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15653632

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546161

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