Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

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http://www.wikidata.org/entity/Q28273012
Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cellsDiscovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells.Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors.Bortezomib overcomes MGMT-related resistance of glioblastoma cell lines to temozolomide in a schedule-dependent manner.In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing.Glutamine Metabolism in Gliomas.Paeoniflorin Inhibits Migration and Invasion of Human Glioblastoma Cells via Suppression Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition.Downregulation of GLS2 in glioblastoma cells is related to DNA hypermethylation but not to the p53 status.
P2860

Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

Item
http://www.wikidata.org/entity/Q28273012
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2012 nî lūn-bûn
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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Transfection of a human gliobl ...... the cells to alkylating agents
@ast
Transfection of a human gliobl ...... the cells to alkylating agents
@en
Transfection of a human gliobl ...... the cells to alkylating agents
@nl
type
label
Transfection of a human gliobl ...... the cells to alkylating agents
@ast
Transfection of a human gliobl ...... the cells to alkylating agents
@en
Transfection of a human gliobl ...... the cells to alkylating agents
@nl
prefLabel
Transfection of a human gliobl ...... the cells to alkylating agents
@ast
Transfection of a human gliobl ...... the cells to alkylating agents
@en
Transfection of a human gliobl ...... the cells to alkylating agents
@nl
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P2860
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P356
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P5875
P698
P356
P1433
P1476
Transfection of a human gliobl ...... the cells to alkylating agents
@en
P2093
P2860
P304
P31
P356
10.1111/J.1471-4159.2012.07917.X
P407
P433
P478
P577
P5875
P698