One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
about
Kinetics of avibactam inhibition against Class A, C, and D β-lactamasesImmucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytesTransition state analogue discrimination by related purine nucleoside phosphorylasesTransition-state inhibitors of purine salvage and other prospective enzyme targets in malariaInhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase †l -Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside PhosphorylaseGlycal Formation in Crystals of Uridine Phosphorylase ,Methylthioinosine Phosphorylase from Pseudomonas aeruginosa . Structure and Annotation of a Novel Enzyme in Quorum SensingCatalytic site conformations in human PNP by 19F-NMR and crystallography.Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimesStructural analyses reveal two distinct families of nucleoside phosphorylasesTransition StatesThe ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning.Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics.Forodesine: review of preclinical and clinical data.Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analoguesFour generations of transition-state analogues for human purine nucleoside phosphorylase.Determinants of catalytic power and ligand binding in glutamate racemase.Computational methods for de novo protein design and its applications to the human immunodeficiency virus 1, purine nucleoside phosphorylase, ubiquitin specific protease 7, and histone demethylases.Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia.Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.Conformational dynamics in human purine nucleoside phosphorylase with reactants and transition-state analoguesEntropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.Emerging pharmacotherapies for adult patients with acute lymphoblastic leukemia.A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)Purine and pyrimidine pathways as targets in Plasmodium falciparum.Immucillins as antibiotics for T-cell proliferation and malaria.Tight binding enantiomers of pre-clinical drug candidates.Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimicsRemote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase.Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma.Structure and inhibition of a quorum sensing target from Streptococcus pneumoniaeEnzymatic transition state theory and transition state analogue design.Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR.Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.Transition States, analogues, and drug development.Enzyme active site interactions by Raman/FTIR, NMR, and ab initio calculationsAdenine release is fast in MutY-catalyzed hydrolysis of G:A and 8-Oxo-G:A DNA mismatches.Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.
P2860
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P2860
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@ast
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@en
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@nl
type
label
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@ast
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@en
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@nl
prefLabel
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@ast
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@en
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@nl
P2093
P356
P1433
P1476
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
@en
P2093
Bagdassarian CK
Schramm VL
P304
P356
10.1021/BI980658D
P407
P577
1998-06-01T00:00:00Z