about
Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1Ensemble refinement shows conformational flexibility in crystal structures of human complement factor DTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsAn update on recent patents on thrombin inhibitors (2010 - 2013)TFPI1 mediates resistance to doxorubicin in breast cancer cells by inducing a hypoxic-like responseDesigning Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing InhibitionMolecular dynamics study on folding and allostery in RfaH.Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1.Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.Dynamic multiprotein assemblies shape the spatial structure of cell signalingATP antagonizes thrombin-induced signal transduction through 12(S)-HETE and cAMPInsight derived from molecular dynamics simulations into molecular motions, thermodynamics and kinetics of HIV-1 gp120Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin.Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.The spatial structure of cell signaling systems.Polyphosphate suppresses complement via the terminal pathway.Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.Viscoelasticity and Ultrastructure in Coagulation and Inflammation: Two Diverse Techniques, One Conclusion.Characterization of thrombin derived from human recombinant prothrombin.Deciphering Conformational Changes Associated with the Maturation of Thrombin Anion Binding Exosite I.Visualizing correlated motion with HDBSCAN clustering.A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin.Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation.Loop-driven conformational transition between the alternative and collapsed form of prethrombin-2: targeted molecular dynamics study.Mechanistic insights into thrombin's switch between "slow" and "fast" forms.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
name
An ensemble view of thrombin allostery
@ast
An ensemble view of thrombin allostery
@en
An ensemble view of thrombin allostery
@nl
type
label
An ensemble view of thrombin allostery
@ast
An ensemble view of thrombin allostery
@en
An ensemble view of thrombin allostery
@nl
prefLabel
An ensemble view of thrombin allostery
@ast
An ensemble view of thrombin allostery
@en
An ensemble view of thrombin allostery
@nl
P3181
P356
P1433
P1476
An ensemble view of thrombin allostery
@en
P2093
James A Huntington
Stefan M V Freund
P304
P3181
P356
10.1515/HSZ-2012-0178
P407
P577
2012-09-01T00:00:00Z