Designing Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing Inhibition - Wikidata - awgldk - TriplyDB

Designing Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing Inhibition

Designing Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing Inhibition

http://www.wikidata.org/entity/Q29040782

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Development of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder Diseases Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate Synthetic, non-saccharide, glycosaminoglycan mimetics selectively target colon cancer stem cells.Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides.Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitors Plasmin regulation through allosteric, sulfated, small molecules.Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin.Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules.Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders.Synthesis and biological evaluation of some dibenzofuran-piperazine derivatives.Thiocarbamate-linked polysulfonate-peptide conjugates as selective hepatocyte growth factor receptor binders.Discovery methods of coagulation-inhibiting drugs.The promise of sulfated synthetic small molecules as modulators of glycosaminoglycan function.A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin.Polyglycine hydrolases secreted by Pleosporineae fungi that target the linker region of plant class IV chitinases.

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P2860

Designing Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing Inhibition

http://www.wikidata.org/entity/Q29040782

description

2013 nî lūn-bûn

@nan

2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Designing Allosteric Regulator ...... ecules for Inducing Inhibition

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Designing Allosteric Regulator ...... ecules for Inducing Inhibition

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Designing Allosteric Regulator ...... ecules for Inducing Inhibition

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Designing Allosteric Regulator ...... ecules for Inducing Inhibition

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Journal of Medicinal Chemistry

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Designing Allosteric Regulator ...... ecules for Inducing Inhibition

@en

P2093

Akul Y. Mehta

http://www.w3.org/2001/XMLSchema#string

Aurijit Sarkar

http://www.w3.org/2001/XMLSchema#string

May H. Abdel Aziz

http://www.w3.org/2001/XMLSchema#string

Preetpal Singh Sidhu

http://www.w3.org/2001/XMLSchema#string

Qibing Zhou

http://www.w3.org/2001/XMLSchema#string

Umesh R. Desai

http://www.w3.org/2001/XMLSchema#string

P2860

Rational design of potent, small, synthetic allosteric inhibitors of thrombin

A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids

Development and validation of a genetic algorithm for flexible docking

An ensemble view of thrombin allostery

The penultimate rotamer library

Conformational analysis of gamma' peptide (410-427) interactions with thrombin anion binding exosite II.

Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases.

First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa

New advances in the discovery of thrombin and factor Xa inhibitors.

Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.

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5059-5070

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scholarly article

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10.1021/JM400369Q

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12

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56

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2013-06-27T00:00:00Z

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236966787

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23718540

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3717983

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