Structural basis of Smoothened regulation by its extracellular domains - Wikidata - awgldk - TriplyDB

Structural basis of Smoothened regulation by its extracellular domains

Structural basis of Smoothened regulation by its extracellular domains

http://www.wikidata.org/entity/Q28277263

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Structure of the full-length glucagon class B G-protein-coupled receptor.Trafficking to the primary cilium membrane.Membrane cholesterol access into a G-protein-coupled receptor.Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer.Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand Cholesterolomics: An update An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain.Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.Allosteric binding: structures reveal new ways to tame G protein-coupled receptors.Common structural features of cholesterol binding sites in crystallized soluble proteins.Wnt signaling in triple-negative breast cancer.From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases.On the state of crystallography at the dawn of the electron microscopy revolution.Membrane lipids and cell signaling.Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.A new trick for an old lipid.Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region.Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif.Lipid metabolism fattens up hedgehog signaling.A cell based, high throughput assay for quantitative analysis of Hedgehog pathway activation using a Smoothened activation sensor.Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.A Structural Framework for GPCR Chemogenomics: What's In a Residue Number?Current and Future Challenges in GPCR Drug Discovery.Assembly and architecture of the Wnt/β-catenin signalosome at the membrane.Membrane cholesterol effect on the 5-HT2A receptor: Insights into the lipid-induced modulation of an antipsychotic drug target.Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains.Contributions of Noncanonical Smoothened Signaling During Embryonic Development.Endothelial smoothened-dependent hedgehog signaling is not required for sonic hedgehog induced angiogenesis or ischemic tissue repair.G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.In silico studies targeting G-protein coupled receptors for drug research against Parkinson's disease.G protein-coupled receptors: the evolution of structural insight.Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer

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P2860

Structural basis of Smoothened regulation by its extracellular domains

http://www.wikidata.org/entity/Q28277263

description

2016 nî lūn-bûn

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2016 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2016 թվականի հուլիսին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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name

Structural basis of Smoothened regulation by its extracellular domains

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Structural basis of Smoothened regulation by its extracellular domains

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Structural basis of Smoothened regulation by its extracellular domains

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label

Structural basis of Smoothened regulation by its extracellular domains

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Structural basis of Smoothened regulation by its extracellular domains

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Structural basis of Smoothened regulation by its extracellular domains

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Structural basis of Smoothened regulation by its extracellular domains

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Structural basis of Smoothened regulation by its extracellular domains

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Structural basis of Smoothened regulation by its extracellular domains

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Structural basis of Smoothened regulation by its extracellular domains

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Christian Siebold

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Douglas F Covey

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George Hedger

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Giovanni Luchetti

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Laurel Mydock-McGrane

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Rajat Rohatgi

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Ria Sircar

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Robert P Rambo

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Sigrid Nachtergaele

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P2860

Small molecule modulation of Smoothened activity

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

Electrostatics of nanosystems: application to microtubules and the ribosome

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

Structural basis of Wnt recognition by Frizzled

MolProbity: all-atom structure validation for macromolecular crystallography

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Crystal structure of a human GABAA receptor

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517-522

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scholarly article

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10.1038/NATURE18934

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7613

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535

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Mark S.P. Sansom

Eamon F X Byrne

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2016-07-20T00:00:00Z

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1038117281

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