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Structural basis of Smoothened regulation by its extracellular domainsProduction of disulfide-stabilized transmembrane peptide complexes for structural studies.Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.Cilia-Associated Oxysterols Activate SmoothenedA serine in the first transmembrane domain of the human E3 ubiquitin ligase MARCH9 is critical for down-regulation of its protein substrates
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description
investigador
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researcher
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wetenschapper
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name
Eamon F X Byrne
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Eamon F X Byrne
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type
label
Eamon F X Byrne
@en
Eamon F X Byrne
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prefLabel
Eamon F X Byrne
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Eamon F X Byrne
@nl
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0000-0001-7513-5944