about
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerVoltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function researchTranscriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemiaThe role of Cdc25A in the regulation of cell proliferation and apoptosisRole of protein tyrosine phosphatases in cancerSolution NMR studies reveal no global flexibility in the catalytic domain of CDC25B.Tumor suppressor function of miR-483-3p on squamous cell carcinomas due to its pro-apoptotic properties.Integrated analysis of copy number variation and genome-wide expression profiling in colorectal cancer tissuesImage-based screening for the identification of novel proteasome inhibitors.Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening.Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypesUnscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage.Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine.The design of novel inhibitors for treating cancer by targeting CDC25B through disruption of CDC25B-CDK2/Cyclin A interaction using computational approaches.Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cellsCasein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistanceSingle amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer.A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradationAnti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma.Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core StructureProtein tyrosine phosphatases as potential therapeutic targets.DNA damage signaling is activated during cancer progression in human colorectal carcinoma.CDC25A(Q110del): a novel cell division cycle 25A isoform aberrantly expressed in non-small cell lung cancerNovel interactions between FOXM1 and CDC25A regulate the cell cycle.Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cellsSTK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosisCDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar fociInhibition of CDC25B phosphatase through disruption of protein-protein interactionString (Cdc25) regulates stem cell maintenance, proliferation and aging in Drosophila testis.MicroRNA let-7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular CarcinomaThe Protein Phosphatases and Protein Kinases of Arabidopsis thalianaCyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteinsLigand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cellsCell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.A molecular understanding of D-homoestrone-induced G2/M cell cycle arrest in HeLa human cervical carcinoma cellsInvestigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Cdc25 phosphatases and cancer
@ast
Cdc25 phosphatases and cancer
@en
Cdc25 phosphatases and cancer
@nl
type
label
Cdc25 phosphatases and cancer
@ast
Cdc25 phosphatases and cancer
@en
Cdc25 phosphatases and cancer
@nl
prefLabel
Cdc25 phosphatases and cancer
@ast
Cdc25 phosphatases and cancer
@en
Cdc25 phosphatases and cancer
@nl
P3181
P1476
Cdc25 phosphatases and cancer
@en
P2093
K Kristjánsdóttir
P304
P3181
P356
10.1016/J.CHEMBIOL.2004.07.007
P407
P577
2004-08-01T00:00:00Z