The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes - Wikidata - awgldk - TriplyDB

The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

http://www.wikidata.org/entity/Q28280371

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Bile acid transporters in health and disease The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis Bile acid transporters Protein-protein interactions and membrane localization of the human organic solute transporter Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents Role of the intestinal bile acid transporters in bile acid and drug disposition Nutritional lipidomics: molecular metabolism, analytics, and diagnostics Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine.Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes Neurosteroid transport by the organic solute transporter OSTα-OSTβ.Clinical application of transcriptional activators of bile salt transporters.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Bile formation and secretion.Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2).The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: a transporter for steroid-derived molecules Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease.Deciphering the nuclear bile acid receptor FXR paradigm.Tissue-specific function of farnesoid X receptor in liver and intestine Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity.Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice.The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.New perspectives for the treatment of cholestasis: lessons from basic science applied clinically.Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARα(PAC) mice due to dysregulated bile acid synthesis Recent advances in small bowel diseases: Part II.Nuclear bile acid receptor FXR as pharmacological target: are we there yet?FXR and PXR: potential therapeutic targets in cholestasis.Does abnormal bile acid metabolism contribute to NEC?Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.Arachidonic acid-induced expression of the organic solute and steroid transporter-beta (Ost-beta) in a cartilaginous fish cell line Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver.Nuclear factor-κB regulates the expression of multiple genes encoding liver transport proteins.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.

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The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

http://www.wikidata.org/entity/Q28280371

description

2006 nî lūn-bûn

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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prefLabel

The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

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AJPGI.00430.2005

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American Journal of Physiology - Gastrointestinal and Liver Physiology

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The nuclear receptor for bile ...... nsporter-alpha and -beta genes

@en

P2093

Gerd A Kullak-Ublick

http://www.w3.org/2001/XMLSchema#string

Jyrki J Eloranta

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Stephan R Vavricka

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P2860

Identification of a nuclear receptor for bile acids

Bile acids: natural ligands for an orphan nuclear receptor

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta

The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

Bile acid-induced negative feedback regulation of the human ileal bile acid transporter

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

Molecular cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol

Enterohepatic bile salt transporters in normal physiology and liver disease

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G476-85

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scholarly article

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10.1152/AJPGI.00430.2005

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3

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290

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Jean-Francois Landrier

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2005-11-03T00:00:00Z

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7497616

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