Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist

Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist

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http://www.wikidata.org/entity/Q28281562

Q28281562

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Potential roles of GPR120 and its agonists in the management of diabetes The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1 Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Lipid receptors and islet function: therapeutic implications?The saturated fatty acid, palmitic acid, induces anxiety-like behavior in mice.Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40.Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY.Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes.Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.Heterodimerisation of G protein-coupled receptors: implications for drug design and ligand screening.Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.The Role and Future of FFA1 as a Therapeutic Target.Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells.Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids.Effects of a treatment with Se-rich rice flour high in resistant starch on enteric dysbiosis and chronic inflammation in diabetic ICR mice.Ligands at Free Fatty Acid Receptor 1 (GPR40).A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice

P2860

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P2860

Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist

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http://www.wikidata.org/entity/Q28281562

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2007 nî lūn-bûn

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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2007年の論文

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