Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids.
about
Pharmacology and physiology of gastrointestinal enteroendocrine cellsPotential roles of GPR120 and its agonists in the management of diabetesGPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein.Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptorsOmega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells.Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 AgonistThe pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonismA Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure.Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.The therapeutic potential of GPR120: a patent review.Treatment of type 2 diabetes by free Fatty Acid receptor agonists.Eicosopentaneoic Acid and Other Free Fatty Acid Receptor Agonists Inhibit Lysophosphatidic Acid- and Epidermal Growth Factor-Induced Proliferation of Human Breast Cancer CellsConcomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469.The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).Application of GPCR Structures for Modelling of Free Fatty Acid Receptors.Free Fatty Acid Receptors and Cancer: From Nutrition to Pharmacology.Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.Grifolic acid induces GH3 adenoma cell death by inhibiting ATP production through a GPR120-independent mechanism.
P2860
Q26799380-2FAF50CE-267C-4A35-9BB8-5CC1633E1A94Q26827101-29E9188E-70EF-46B3-BCB6-AB2502A589C4Q33600207-F610BCCC-46F3-4BFB-87FE-14B35404A5D2Q34107213-F7803AC3-2A58-4379-818E-ACFF0D7FD914Q34121932-E9CDBB56-D54F-4987-A0EA-48921369BD72Q34946548-1DE8D276-80B4-4174-BA91-0F0818FC12C1Q35178871-EFF4BAE7-BF20-44AD-B8E4-D8F032183AA9Q37252074-BDF9F725-7C71-4EB9-8F1B-17E35729DAFBQ37582024-D827A2CB-273A-4347-86FE-2057B18DCBC9Q38014830-FCED1D23-973B-4465-9ED3-46D998814DC8Q38149330-464D5BB1-1818-44C8-AFAD-8C8E3D36DC6BQ38249182-1CB2A5E2-ADDE-409A-B2ED-7673C1244D94Q38711479-496B8C2E-A46E-44D7-93DA-026DC9BC6004Q38996098-D191F7D6-6F59-4FC7-A378-573AD3E89EC0Q39124913-DE775AD7-C607-478F-A4D2-6EEFA66F0798Q39186814-8B674154-0C82-441D-990F-E5DF41CEAE43Q39273205-2BAE20C5-0BAB-4D07-898E-F4E8E90E812AQ39273221-3A3A59EF-5E13-4A0D-AE47-35342547DF3FQ40112219-57A5E174-BF6F-4B41-B31F-534A67AC167BQ47096380-0E45FE5B-AAC9-4C7B-8EE0-39E656CC1F34Q55255751-9327198D-2E01-4E15-B45A-AA954C20FDB2
P2860
Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Drug discovery opportunities a ...... r long chain free Fatty acids.
@en
Drug discovery opportunities a ...... r long chain free Fatty acids.
@nl
type
label
Drug discovery opportunities a ...... r long chain free Fatty acids.
@en
Drug discovery opportunities a ...... r long chain free Fatty acids.
@nl
prefLabel
Drug discovery opportunities a ...... r long chain free Fatty acids.
@en
Drug discovery opportunities a ...... r long chain free Fatty acids.
@nl
P2860
P356
P1476
Drug discovery opportunities a ...... r long chain free Fatty acids.
@en
P2093
Alastair J H Brown
Sarah-Jane Watson
P2860
P356
10.3389/FENDO.2011.00112
P577
2011-01-01T00:00:00Z