Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy
about
A new mutation of the cardiac troponin T gene causing familial hypertrophic cardiomyopathy without left ventricular hypertrophyDisease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding regionPhosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocityA calcineurin-dependent transcriptional pathway for cardiac hypertrophyThin filament mutations: developing an integrative approach to a complex disorderAltered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathyA truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathyRegulation of force and unloaded sliding speed in single thin filaments: effects of regulatory proteins and calciumCardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathyA Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function.Identification of a contractile deficit in adult cardiac myocytes expressing hypertrophic cardiomyopathy-associated mutant troponin T proteins.Molecular polarity in tropomyosin-troponin T co-crystalsThe molecular genetic basis for hypertrophic cardiomyopathy.Cardiac troponin T (TNNT2) mutations in chinese dilated cardiomyopathy patientsMolecular genetics and pathogenesis of hypertrophic cardiomyopathy.Three-dimensional reconstruction of thin filaments containing mutant tropomyosinRegulatory proteins alter nucleotide binding to acto-myosin of sliding filaments in motility assaysCa2+ regulation of rabbit skeletal muscle thin filament sliding: role of cross-bridge number.Use of fluorescent techniques to study the in vitro movement of myosinsDual regulatory functions of the thin filament revealed by replacement of the troponin I inhibitory peptide with a linkerDevelopmentally regulated, alternative RNA splicing-generated pectoral muscle-specific troponin T isoforms and role of the NH2-terminal hypervariable region in the tolerance to acidosis.Clinical phenotype and outcome of hypertrophic cardiomyopathy associated with thin-filament gene mutations.Molecular mechanisms of inherited cardiomyopathies.Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.Hypertrophic cardiomyopathy: from gene defect to clinical disease.Facilitated cross-bridge interactions with thin filaments by familial hypertrophic cardiomyopathy mutations in α-tropomyosin.Ca2+-dependent muscle dysfunction caused by mutation of the Caenorhabditis elegans troponin T-1 geneSpecific myosin heavy chain mutations suppress troponin I defects in Drosophila musclesMolecular genetics in hypertrophic cardiomyopathy: towards individualized management of the disease.Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: a novel pathogenic mechanism for hypertrophic cardiomyopathy.Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function.Analysis of the molecular pathogenesis of cardiomyopathy-causing cTnT mutants I79N, ΔE96, and ΔK210.TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.Do cardiac actin mutations lead to altered actomyosin interactions?Role of residues 311/312 in actin-tropomyosin interaction. In vitro motility study using yeast actin mutant e311a/r312a.The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin.Troponin I and troponin T interact with troponin C to produce different Ca2+-dependent effects on actin-tropomyosin filament motility.Cardiac troponin T isoforms demonstrate similar effects on mechanical performance in a regulated contractile system.Effects of all-trans retinoic acid on angiotensin II-induced myocyte hypertrophy.Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding.
P2860
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P2860
Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@ast
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@en
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@nl
type
label
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@ast
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@en
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@nl
prefLabel
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@ast
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@en
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@nl
P2093
P2860
P356
P1476
Altered cardiac troponin T in ...... al hypertrophic cardiomyopathy
@en
P2093
P2860
P304
P356
10.1172/JCI118740
P407
P577
1996-06-15T00:00:00Z