Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function.
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Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian DescendantsDisease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding regionRegulation of force and unloaded sliding speed in single thin filaments: effects of regulatory proteins and calciumCardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathyDecreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin TIdentification of a contractile deficit in adult cardiac myocytes expressing hypertrophic cardiomyopathy-associated mutant troponin T proteins.The molecular genetic basis for hypertrophic cardiomyopathy.Cardiac troponin T (TNNT2) mutations in chinese dilated cardiomyopathy patientsHypertrophic cardiomyopathy: from genetics to treatmentExperimental therapies in hypertrophic cardiomyopathyMolecular genetics and pathogenesis of hypertrophic cardiomyopathy.Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction.Elementary steps of the cross-bridge cycle in bovine myocardium with and without regulatory proteins.Regulatory proteins alter nucleotide binding to acto-myosin of sliding filaments in motility assaysCa2+ regulation of rabbit skeletal muscle thin filament sliding: role of cross-bridge number.Molecular mechanisms of inherited cardiomyopathies.Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.Facilitated cross-bridge interactions with thin filaments by familial hypertrophic cardiomyopathy mutations in α-tropomyosin.Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affairCa2+-dependent muscle dysfunction caused by mutation of the Caenorhabditis elegans troponin T-1 geneMyofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Alternative splicing, muscle calcium sensitivity, and the modulation of dragonfly flight performance.Analysis of the molecular pathogenesis of cardiomyopathy-causing cTnT mutants I79N, ΔE96, and ΔK210.HCM-linked ∆160E cardiac troponin T mutation causes unique progressive structural and molecular ventricular remodeling in transgenic mice.Designing heart performance by gene transfer.Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation?Mechanisms of disease: hypertrophic cardiomyopathy.Exon skipping in cardiac troponin T of turkeys with inherited dilated cardiomyopathy.Untangling the Biology of Genetic Cardiomyopathies with Pluripotent Stem Cell Disease Models.Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes.Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.Hypothesis and theory: mechanical instabilities and non-uniformities in hereditary sarcomere myopathies.Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart.Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding.There is no slowing of motility speed with increased body size in rat, human, horse and rhinoceros independent on temperature and skeletal muscle myosin isoform.Fast skeletal muscle troponin T increases the cooperativity of transgenic mouse cardiac muscle contraction.Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction
P2860
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P2860
Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Functional analyses of troponi ...... genesis and troponin function.
@ast
Functional analyses of troponi ...... genesis and troponin function.
@en
type
label
Functional analyses of troponi ...... genesis and troponin function.
@ast
Functional analyses of troponi ...... genesis and troponin function.
@en
prefLabel
Functional analyses of troponi ...... genesis and troponin function.
@ast
Functional analyses of troponi ...... genesis and troponin function.
@en
P2093
P2860
P356
P1476
Functional analyses of troponi ...... genesis and troponin function.
@en
P2093
P2860
P304
14406-14410
P356
10.1073/PNAS.95.24.14406
P407
P577
1998-11-01T00:00:00Z