DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
about
Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeastBiochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesDNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNAIntravesical therapy for non-muscle invasive bladder cancer: a network meta-analysisQuinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of ActionsMammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomicsTherapeutic strategies targeting cancer stem cellsInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyDNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosisDrugging topoisomerases: lessons and challengesA review of conventional and drug-eluting chemoembolization in the treatment of colorectal liver metastases: principles and proofOvercoming multidrug resistance via photodestruction of ABCG2-rich extracellular vesicles sequestering photosensitive chemotherapeuticsActivation of new replication foci under conditions of replication stress.EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumorsImmunodetection of human topoisomerase I-DNA covalent complexesA cell-based screen reveals that the albendazole metabolite, albendazole sulfone, targets WolbachiaStructural basis of type II topoisomerase inhibition by the anticancer drug etoposideThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA CleavageStructural basis for recognition of 5′-phosphotyrosine adducts by Tdp2Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transportOn the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugsA New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of InhibitionProteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory proteinTargeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide ConjugationAssessment of the topoisomerase I gene copy number as a predictive biomarker of objective response to irinotecan in metastatic colorectal cancer.Mitoxantrone-Surfactant Interactions: A Physicochemical OverviewMolecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid LeukemiaUnderstanding the structural mechanisms of antibiotic resistance sets the platform for new discoveryTDP2 protects transcription from abortive topoisomerase activity and is required for normal neural functionTopoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sitesLeukotriene C4 is the major trigger of stress-induced oxidative DNA damageAn integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase IIHeterogeneous role of the glutathione antioxidant system in modulating the response of ESFT to fenretinide in normoxia and hypoxiaUnprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravirFunctional DNA repair signature of cancer cell lines exposed to a set of cytotoxic anticancer drugs using a multiplexed enzymatic repair assay on biochipApplication of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VISolvent dependency of the UV-Vis spectrum of indenoisoquinolines: role of keto-oxygens as polarity interaction probesToward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platformA high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response
P2860
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P2860
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@ast
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@en
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@nl
type
label
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@ast
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@en
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@nl
prefLabel
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@ast
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@en
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@nl
P2093
P3181
P1476
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
@en
P2093
Christophe Marchand
Elisabetta Leo
HongLiang Zhang
P304
P3181
P356
10.1016/J.CHEMBIOL.2010.04.012
P407
P50
P577
2010-05-28T00:00:00Z