Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)
about
Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channelsKCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemiaUnstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activationPharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressureMolecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neuronsIntermediate-conductance calcium-activated potassium channels participate in neurovascular coupling.Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic ratsThe activation effect of hainantoxin-I, a peptide toxin from the Chinese spider, Ornithoctonus hainana, on intermediate-conductance Ca2+-activated K+ channels.New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.Upregulation of SK3 and IK1 channels contributes to the enhanced endothelial calcium signaling and the preserved coronary relaxation in obese Zucker rats.Role of in vivo vascular redox in resistance arteriesFundamental increase in pressure-dependent constriction of brain parenchymal arterioles from subarachnoid hemorrhage model rats due to membrane depolarization.Electrostatic influences of charged inner pore residues on the conductance and gating of small conductance Ca2+ activated K+ channels.Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels.Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin InterfacePharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility.Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons.Therapeutic potential of KCa3.1 blockers: recent advances and promising trends.Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives.Activation of endothelial and epithelial K(Ca) 2.3 calcium-activated potassium channels by NS309 relaxes human small pulmonary arteries and bronchioles.Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons.Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membraneKCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS.NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels.Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signalingEndothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexesOpeners of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilationK+ channel modulators for the treatment of neurological disorders and autoimmune diseasesThe therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseasesEndothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's diseaseCalcium-activated potassium channels and endothelial dysfunction: therapeutic options?Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neuronsEndothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discoveryInhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels.
P2860
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P2860
Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@ast
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@en
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@nl
type
label
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@ast
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@en
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@nl
prefLabel
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@ast
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@en
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@nl
P2093
P1476
Activation of human IK and SK ...... o-1H-indole-2,3-dione 3-oxime)
@en
P2093
Bo Skaaning-Jensen
Dorte Strøbaek
Katrine Kjaer
Lene Teuber
Palle Christophersen
Philip K Ahring
Rie S Hansen
Søren Peter Olesen
Tino D Jørgensen
P356
10.1016/J.BBAMEM.2004.07.006
P407
P577
2004-10-11T00:00:00Z