LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution
about
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activityFrizzled homolog proteins, microRNAs and Wnt signaling in cancerStructural Insight into the Mechanisms of Wnt Signaling Antagonism by DkkTwo Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathwayDkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation.Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.Low-density lipoprotein receptor-related protein 6 (LRP6) rs10845498 polymorphism is associated with a decreased risk of non-small cell lung cancerWnt inhibitory factor 1 (WIF1) methylation and its association with clinical prognosis in patients with chondrosarcoma.LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy.Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cellsUpregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasionA novel sLRP6E1E2 inhibits canonical Wnt signaling, epithelial-to-mesenchymal transition, and induces mitochondria-dependent apoptosis in lung cancer.MiR-126-3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2.The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.Downregulation of miR-610 promotes proliferation and tumorigenicity and activates Wnt/β-catenin signaling in human hepatocellular carcinoma.Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type β propeller domains.Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation.A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents.Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells.Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.LRP5/6 in Wnt signaling and tumorigenesis.Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway.Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion.Combined treatment with chrysin and 1,2,3,4,6-penta-O-galloyl-β-D-glucose synergistically inhibits LRP6 and Skp2 activation in triple-negative breast cancer and xenografts.miR-202 suppresses cell proliferation in human hepatocellular carcinoma by downregulating LRP6 post-transcriptionally.MicroRNA-183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP6.LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS.Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma.MicroRNA-610 inhibits tumor growth of melanoma by targeting LRP6.Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling.Pattern of LRP6 gene expression in tumoral tissues of colorectal cancer.LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers.
P2860
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P2860
LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
LRP6 expression promotes cance ...... tenin subcellular distribution
@ast
LRP6 expression promotes cance ...... tenin subcellular distribution
@en
LRP6 expression promotes cance ...... tenin subcellular distribution
@nl
type
label
LRP6 expression promotes cance ...... tenin subcellular distribution
@ast
LRP6 expression promotes cance ...... tenin subcellular distribution
@en
LRP6 expression promotes cance ...... tenin subcellular distribution
@nl
prefLabel
LRP6 expression promotes cance ...... tenin subcellular distribution
@ast
LRP6 expression promotes cance ...... tenin subcellular distribution
@en
LRP6 expression promotes cance ...... tenin subcellular distribution
@nl
P2093
P2860
P356
P1433
P1476
LRP6 expression promotes cance ...... tenin subcellular distribution
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208123
P407
P577
2004-12-02T00:00:00Z
P5875
P6179
1010258606