Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration
about
Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide ProcessingRegulation of Chemokine Activity - A Focus on the Role of Dipeptidyl Peptidase IV/CD26Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effectsAngiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3.IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammationConvolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytesHIV persistence: chemokines and their signalling pathways.Biological activity of CXCL8 forms generated by alternative cleavage of the signal peptide or by aminopeptidase-mediated truncation.Posttranslational modification of the NH2-terminal region of CXCL5 by proteases or peptidylarginine Deiminases (PAD) differently affects its biological activityNeutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines.Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironmentImmune escape to PD-L1/PD-1 blockade: seven steps to success (or failure).Multiple roles for chemokines in the pathogenesis of SIV infectionCD14 in the TLRs signaling pathway is associated with the resistance to E. coli F18 in Chinese domestic weaned piglets.Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation.Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammationInhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studiesNatural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo.The dipeptidyl peptidase IV family in cancer and cell biology.The blood-brain barrier, chemokines and multiple sclerosisEctoenzymes controlling leukocyte traffic.Deciphering and reversing tumor immune suppression.Ectoenzymes in leukocyte migration and their therapeutic potential.Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling.Overview and potential unifying themes of the atypical chemokine receptor family.CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology.CD26 and Asthma: a Comprehensive Review.Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer.Human type II pneumocyte chemotactic responses to CXCR3 activation are mediated by splice variant A.T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapyExpression and function of aminopeptidase N/CD13 produced by fibroblast-like synoviocytes in rheumatoid arthritis: role of CD13 in chemotaxis of cytokine-activated T cells independent of enzymatic activityThe chemokine receptor CXCR7 functions to regulate cardiac valve remodelingDifferent contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.Microarray-based identification of aminopeptidase N target genes in keratinocyte conditioned medium-stimulated dermal fibroblasts.Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle.Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands.Mechanisms regulating T-cell infiltration and activity in solid tumors.IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanism.
P2860
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P2860
Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Proteolytic processing of CXCL ...... and endothelial cell migration
@ast
Proteolytic processing of CXCL ...... and endothelial cell migration
@en
Proteolytic processing of CXCL ...... and endothelial cell migration
@nl
type
label
Proteolytic processing of CXCL ...... and endothelial cell migration
@ast
Proteolytic processing of CXCL ...... and endothelial cell migration
@en
Proteolytic processing of CXCL ...... and endothelial cell migration
@nl
prefLabel
Proteolytic processing of CXCL ...... and endothelial cell migration
@ast
Proteolytic processing of CXCL ...... and endothelial cell migration
@en
Proteolytic processing of CXCL ...... and endothelial cell migration
@nl
P2093
P50
P921
P3181
P1433
P1476
Proteolytic processing of CXCL ...... and endothelial cell migration
@en
P2093
Evemie Schutyser
Isabelle Ronsse
Jo Vandercappellen
Mieke Gouwy
Tamara Loos
P3181
P356
10.1182/BLOOD-2006-10-049072
P407
P577
2007-03-15T00:00:00Z