TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
about
Mutational activation of the MAP3K8 protooncogene in lung cancerABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stabilityThe tyrosine kinase Syk regulates TPL2 activation signalsNF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activityProstaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activationMeaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsAkt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalphaMultiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformationLoss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesisThe COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activityThe oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinaseModular decomposition of protein-protein interaction networksThe Regulation of NF-κB Subunits by PhosphorylationTumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerNF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic ImplicationsbetaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activationASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interactionIdentification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signalingRegulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseMAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomasAltered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout miceComparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8The protein kinase TPL2 is essential for ERK1/ERK2 activation and cytokine gene expression in airway epithelial cells exposed to pathogen-associated molecular patterns (PAMPs)ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responsesGenetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.A global transcriptional view of apoptosis in human T-cell activation.Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity.Tpl2 is a key mediator of arsenite-induced signal transduction.IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinasesPrincipal network analysis: identification of subnetworks representing major dynamics using gene expression data.Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.Roles of the NF-kappaB pathway in lymphocyte development and function.TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth.Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.NOD mice are defective in proteasome production and activation of NF-kappaBInhibiting NF-κB activation by small molecules as a therapeutic strategy.Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells
P2860
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P2860
TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@ast
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@en
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@nl
type
label
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@ast
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@en
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@nl
prefLabel
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@ast
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@en
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@nl
P2093
P3181
P356
P1433
P1476
TPL-2 kinase regulates the pro ...... bitory protein NF-kappaB1 p105
@en
P2093
A Salmerón
L H Johnston
M P Belich
P2888
P3181
P356
10.1038/16946
P407
P577
1999-01-28T00:00:00Z
P6179
1045760180