Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy - Wikidata - awgldk - TriplyDB

Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy

Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy

http://www.wikidata.org/entity/Q28297222

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Kindlin-2 is required for myocyte elongation and is essential for myogenesis Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies.Developmental and pathogenic mechanisms of basement membrane assembly The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy Distinct roles for laminin globular domains in laminin alpha1 chain mediated rescue of murine laminin alpha2 chain deficiency Satellite cells: regenerative mechanisms and applicability in muscular dystrophy Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy Hanging on for the ride: adhesion to the extracellular matrix mediates cellular responses in skeletal muscle morphogenesis and disease AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy The Dystrophin Complex: Structure, Function, and Implications for Therapy NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin-dependent manner.Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin.Transgenic expression of Laminin α1 chain does not prevent muscle disease in the mdx mouse model for Duchenne muscular dystrophy.VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects.Duchenne muscular dystrophy gene therapy: Lost in translation?Alpha7beta1 integrin does not alleviate disease in a mouse model of limb girdle muscular dystrophy type 2F β4 integrin marks interstitial myogenic progenitor cells in adult murine skeletal muscle.β1D chain increases α7β1 integrin and laminin and protects against sarcolemmal damage in mdx mice microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice.Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency.Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage.Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression.Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy.Sub-physiological sarcoglycan expression contributes to compensatory muscle protection in mdx mice Levels of α7 integrin and laminin-α2 are increased following prednisone treatment in the mdx mouse and GRMD dog models of Duchenne muscular dystrophy.Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.Alpha 7 integrin preserves the function of the extensor digitorum longus muscle in dystrophin-null mice.Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin Skeletal muscle as a paradigm for regenerative biology and medicine.Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.AAV-directed muscular dystrophy gene therapy.Cell-matrix interactions in muscle disease.Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.Silk fibroin scaffolds enhance cell commitment of adult rat cardiac progenitor cells.Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160.Mesothelioma cells breaking bad: loss of integrin α7 promotes cell motility and poor clinical outcomes in patients.

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Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy

http://www.wikidata.org/entity/Q28297222

description

2006 nî lūn-bûn

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2006 թուականի Մարտին հրատարակուած գիտական յօդուած

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2006 թվականի մարտին հրատարակված գիտական հոդված

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Absence of alpha 7 integrin in ...... to Duchenne muscular dystrophy

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Human Molecular Genetics

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Absence of alpha 7 integrin in ...... to Duchenne muscular dystrophy

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Alexander Werner

http://www.w3.org/2001/XMLSchema#string

Chun Guo

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Gennadij Raivich

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Ludwig Neyses

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Michael Emerson

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Michael Willem

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Ulrike Mayer

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P2860

Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy

Mutations in the integrin alpha7 gene cause congenital myopathy

Absence of integrin alpha 7 causes a novel form of muscular dystrophy

Different dystrophin-like complexes are expressed in neurons and glia

Integrins: bidirectional, allosteric signaling machines

Dissociation of the dystroglycan complex in caveolin-3-deficient limb girdle muscular dystrophy

Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues

Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy

Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy

Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle

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10.1093/HMG/DDL018

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6

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15

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16476707

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