Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I
about
The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent mannerINPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouseStructures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylationProtein prenylation and synaptic plasticity: implications for Alzheimer's diseaseThe physiology of protein S-acylationStructure of Protein Geranylgeranyltransferase-I from the Human Pathogen Candida albicans Complexed with a Lipid SubstrateStructural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein FarnesyltransferaseStructure-guided development of selective RabGGTase inhibitorsCrystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designGeranylgeranyl diphosphate synthase: an emerging therapeutic targetTowards the systematic mapping and engineering of the protein prenylation machinery in Saccharomyces cerevisiaeMulti-SNP analysis of GWAS data identifies pathways associated with nonalcoholic fatty liver diseaseDiversity of heterotrimeric G-protein γ subunits in plantsDrug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity.Multiple domain insertions and losses in the evolution of the Rab prenylation complex.The role of lipid post-translational modification in plant developmental processesIn vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-ISynthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substratesPurification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferaseThe CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypesMeasurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitorsTargeting protein prenylation for cancer therapyThe transposon impala is activated by low temperatures: use of a controlled transposition system to identify genes critical for viability of Aspergillus fumigatusStatins impair CD1d-mediated antigen presentation through the inhibition of prenylation.Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.Sip1, an AP-1 accessory protein in fission yeast, is required for localization of Rho3 GTPase.RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segmentsFarnesyl transferase expression determines clinical response to the docetaxel-lonafarnib combination in patients with advanced malignancies.Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism.Lonafarnib is a potential inhibitor for neovascularization.Rab proteins and the compartmentalization of the endosomal systemIsoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.Evaluation of a cell penetrating prenylated peptide lacking an intrinsic fluorophore via in situ click reaction.Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.Molecular targets for tumor radiosensitization.Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.
P2860
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P2860
Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Thematic review series: lipid ...... ranylgeranyltransferase type I
@ast
Thematic review series: lipid ...... ranylgeranyltransferase type I
@en
Thematic review series: lipid ...... ranylgeranyltransferase type I
@nl
type
label
Thematic review series: lipid ...... ranylgeranyltransferase type I
@ast
Thematic review series: lipid ...... ranylgeranyltransferase type I
@en
Thematic review series: lipid ...... ranylgeranyltransferase type I
@nl
prefLabel
Thematic review series: lipid ...... ranylgeranyltransferase type I
@ast
Thematic review series: lipid ...... ranylgeranyltransferase type I
@en
Thematic review series: lipid ...... ranylgeranyltransferase type I
@nl
P1476
Thematic review series: lipid ...... ranylgeranyltransferase type I
@en
P2093
Kimberly T Lane
Lorena S Beese
P304
P356
10.1194/JLR.R600002-JLR200
P407
P577
2006-04-01T00:00:00Z