Biochemical analysis of MEK activation in NIH3T3 fibroblasts. Identification of B-Raf and other activators
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A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK functionMEK kinase activity is not necessary for Raf-1 function.Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathwayConditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cellsc-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylationAutoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritisEssential role of B-Raf in ERK activation during extraembryonic developmentActivation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation.Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway.A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosisMolecular pathology of thyroid cancer: diagnostic and clinical implications.Activation of B-Raf and regulation of the mitogen-activated protein kinase pathway by the G(o) alpha chain.Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: evidence for a potential novel pathway.Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 geneInhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cellsDifferential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes.Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase.Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling.Efficacy of agonist-stimulated MEK activation determines the susceptibility of mitogen-activated protein (MAP) kinase to inhibition in rat aortic smooth muscle cells.Genetics of papillary thyroid cancer initiation: implications for therapyFibronectin modulates the effects of HIV-1 Tat on the growth of murine Kaposi's sarcoma-like cells through the down-regulation of tyrosine phosphorylation.BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERKTrypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases.
P2860
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P2860
Biochemical analysis of MEK activation in NIH3T3 fibroblasts. Identification of B-Raf and other activators
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@ast
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@en
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@nl
type
label
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@ast
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@en
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@nl
prefLabel
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@ast
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@en
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@nl
P2093
P1476
Biochemical analysis of MEK ac ...... of B-Raf and other activators
@en
P2093
A D Catling
C W Reuter
P304
P407
P577
1995-03-31T00:00:00Z