A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewProtein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardiumCardiac thin filament regulationLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationMultiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human HeartTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation.PKCβII modulation of myocyte contractile performance.Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments.Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinityEffects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.10,000-fold concentration increase in proteins in a cascade microchip using anionic ITP by a 3-D numerical simulation with experimental results.Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade microchip by cationic isotachophoresisAugmented phosphorylation of cardiac troponin I in hypertensive heart failure.10,000-fold concentration increase of the biomarker cardiac troponin I in a reducing union microfluidic chip using cationic isotachophoresis.Phosphorylation of contractile proteins in response to alpha- and beta-adrenergic stimulation in neonatal cardiomyocytesSingle amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry.In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.Negative charges at protein kinase C sites of troponin I stabilize the inactive state of actinRapid large-scale purification of myofilament proteins using a cleavable His6-tag.Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins.Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytesThe role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.Ala scanning of the inhibitory region of cardiac troponin I.Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration.Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation.Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart-detrimental or beneficial?Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice.Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry.Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments.The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform.Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium
P2860
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P2860
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A non-equilibrium isoelectric ...... horylation by protein kinase C
@ast
A non-equilibrium isoelectric ...... horylation by protein kinase C
@en
A non-equilibrium isoelectric ...... horylation by protein kinase C
@nl
type
label
A non-equilibrium isoelectric ...... horylation by protein kinase C
@ast
A non-equilibrium isoelectric ...... horylation by protein kinase C
@en
A non-equilibrium isoelectric ...... horylation by protein kinase C
@nl
prefLabel
A non-equilibrium isoelectric ...... horylation by protein kinase C
@ast
A non-equilibrium isoelectric ...... horylation by protein kinase C
@en
A non-equilibrium isoelectric ...... horylation by protein kinase C
@nl
P2093
P1476
A non-equilibrium isoelectric ...... horylation by protein kinase C
@en
P2093
R John Solaro
Tomoyoshi Kobayashi
Xiaofeng Yang
P356
10.1016/J.YJMCC.2004.10.014
P407
P577
2005-01-01T00:00:00Z