Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion

Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion

Item

http://www.wikidata.org/entity/Q28301027

Q28301027

about

Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.Variants in the FFAR1 gene are associated with beta cell function.An islet in distress: β cell failure in type 2 diabetes.PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells Nutritional regulation of insulin secretion: implications for diabetes.Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases.Fatty acid receptors as new therapeutic targets for diabetes.Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.The endocrinology of taste receptors.The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.Biological characteristics and agonists of GPR120 (FFAR4) receptor: the present status of research.The Role and Future of FFA1 as a Therapeutic Target.Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells.For Better or Worse: FFAR1 and FFAR4 Signaling in Cancer and Diabetes.A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes.Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic β-Cells.Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine.Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids.Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance.Lack of GPR40/FFAR1 does not induce diabetes even under insulin resistance condition.Expression of long-chain fatty acid receptor GPR40 is associated with cancer progression in colorectal cancer: A retrospective study.

P2860

Q27865234-6C822D7C-D457-4AD9-AE5F-24D912882D7E Q33305200-4D095416-974C-46D3-ADB5-2F85474521B0 Q33558360-8CDC44A1-4EDD-4735-9442-04F05E26FCA2 Q34570823-1A71B58A-B2F6-4929-8B3C-BDE33BF6F8BB Q36071152-7636EAC1-8527-45E0-8343-741134C84166 Q36165684-375F2417-70F8-456C-93AF-31A5E9878567 Q36804437-41065913-21EC-4D2E-981C-DE1425F08833 Q36807640-9FFA1BE0-3F4F-47BA-8770-CBE090FEA06C Q36842612-7E86699B-8693-4DE4-90AC-A57ABD65A419 Q37571440-65F8F5CF-F375-41D2-84BA-68E91B153038 Q38259563-9AE56714-7AE7-47FE-91A7-EC266C00813F Q38325894-8096FBD0-36FB-4B3C-BDBE-9630C2BDA6F0 Q38558377-D3F2C877-2FEE-4EEE-8C9C-47B98CCA5A57 Q38799812-8AA360F1-FF88-42E7-B1D4-66F16C93F51B Q38838656-4B1D49E8-3488-468D-9FC6-50731E8A02B3 Q38943148-0DD67932-894B-4561-86EC-09AE80F05092 Q41248825-5C8F37C6-5297-406A-8ADD-E0B0D571113C Q41848207-F704B1C6-FC51-4B17-B986-A42C0479D4C0 Q42141283-EB0E3021-7278-46AB-8563-766AFAAD8DD9 Q42174959-4D75BD5A-A4B3-44FA-8A1F-DC81544E9146 Q42377874-B0BB9C85-48DD-4180-A9DF-EC1915DAF826 Q43462035-A9CCCEEB-1519-46B3-8363-0AD2AE0877FE Q55124306-B36AC600-28BA-4303-A903-2D639EB9E5D2

P2860

Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion

Item

http://www.wikidata.org/entity/Q28301027

description

2006 nî lūn-bûn

@nan

2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu