Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
about
Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCPECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathwayFunctional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirementsTRAF family proteins link PKR with NF-kappa B activationDNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding propertiesMolecular determinants of NF-kappaB-inducing kinase actionCoordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinaseIkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complexHuman mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascadesOpposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cellsRaf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activationTransactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathwayIkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activityMixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complexThe net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shockActivation of IkappaB kinase beta by protein kinase C isoformsRestoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cellsHNE interacts directly with JNK isoforms in human hepatic stellate cellsSignaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainThe atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathwayI kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domainA new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcriptionMEKK1 activates both IkappaB kinase alpha and IkappaB kinase betaCellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.A RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activationTRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathwaysActivation of oxidative stress-responsive signaling pathways in early splenotoxic response of anilineIdentification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survivalSUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cellsCloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor alpha, and interleukin-1beta: role of CD14 and mitogen-activated protein kinasesIntracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1.Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaBToll-like receptor signaling in cell proliferation and survivalHepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha.Mechanisms of T-cell activation by human T-cell lymphotropic virus type I.Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex.
P2860
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P2860
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@ast
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@en
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@nl
type
label
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@ast
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@en
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@nl
prefLabel
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@ast
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@en
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@nl
P2093
P1433
P1476
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
@en
P2093
P304
P407
P577
1997-01-24T00:00:00Z