The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis
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Structural basis for the dsRNA specificity of the Lassa virus NP exonucleaseBiochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partneringStructure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW DomainsCrystal Structure of CRN-4: Implications for Domain Function in Apoptotic DNA DegradationDefects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune diseaseMutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locusFunctional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'-5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch.Limiting the persistence of a chromosome break diminishes its mutagenic potential.The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleasesDiscovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesisDominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex.WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.Aromatic residues in RNase T stack with nucleobases to guide the sequence-specific recognition and cleavage of nucleic acids.TREX1 acts in degrading damaged DNA from drug-treated tumor cells.DNA binding induces active site conformational change in the human TREX2 3'-exonucleaseThe TREX1 C-terminal region controls cellular localization through ubiquitination.Nucleases: diversity of structure, function and mechanism.Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonucleaseDouble deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.A novel single-stranded DNA-specific 3'-5' exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways
P2860
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P2860
The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@ast
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@en
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@nl
type
label
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@ast
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@en
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@nl
prefLabel
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@ast
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@en
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@nl
P2093
P2860
P356
P1476
The human TREX2 3' -> 5'-exonu ...... nt nonprocessive DNA catalysis
@en
P2093
Fred W Perrino
Sara McMillin
Scott Harvey
Thomas Hollis
P2860
P304
P356
10.1074/JBC.M500108200
P407
P577
2005-04-15T00:00:00Z