DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
about
Genetic susceptibility to lung cancer--light at the end of the tunnel?Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeStructural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domainAberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing geneNFBD1/MDC1 is a protein of oncogenic potential in human cervical cancerDistinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesisDifferential regulation of centrosome integrity by DNA damage response proteins.Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.Mutant TP53 posttranslational modifications: challenges and opportunities.Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell deathA Newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese.Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins.MDC1 cleavage by caspase-3: a novel mechanism for inactivating the DNA damage response during apoptosis.Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors.NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpointTime-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines.A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer.MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer Suppression.Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathwayLoss of BRCA1 expression leads to worse survival in patients with gastric carcinomaUtilizing yeast chemogenomic profiles for the prediction of pharmacogenomic associations in humans.Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy.HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinomaInhibiting the DNA damage response as a therapeutic manoeuvre in cancer.Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repairLoss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes.DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic StabilityDNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer.MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition.Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks.NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53.Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours.NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathwayPatterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment.c-Fos-dependent miR-22 targets MDC1 and regulates DNA repair in terminally differentiated cells.Polymorphisms in homologous recombination repair genes and the risk and survival of breast cancer.53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma.
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P2860
DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
DNA damage response mediators ...... n testicular germ cell tumours
@ast
DNA damage response mediators ...... n testicular germ cell tumours
@en
DNA damage response mediators ...... n testicular germ cell tumours
@nl
type
label
DNA damage response mediators ...... n testicular germ cell tumours
@ast
DNA damage response mediators ...... n testicular germ cell tumours
@en
DNA damage response mediators ...... n testicular germ cell tumours
@nl
prefLabel
DNA damage response mediators ...... n testicular germ cell tumours
@ast
DNA damage response mediators ...... n testicular germ cell tumours
@en
DNA damage response mediators ...... n testicular germ cell tumours
@nl
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DNA damage response mediators ...... n testicular germ cell tumours
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10.1038/SJ.ONC.1210553
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2007-11-22T00:00:00Z
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1000835355