A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
about
Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivationNHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membraneTIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cellsFocus on PTEN RegulationBiophysical methods for the characterization of PTEN/lipid bilayer interactionsPtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanismPhosphoinositides: tiny lipids with giant impact on cell regulationSubcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disordersManipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biologyPTEN hopping on the cell membrane is regulated via a positively-charged C2 domainNovel protein Callipygian defines the back of migrating cells.A glutamate switch controls voltage-sensitive phosphatase functionTherapeutic targeting of cancers with loss of PTEN function.PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastomaDeletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptationPTEN regulates cilia through Dishevelled.The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activityThe PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapyA phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migrationDifferential regulation of proton-sensitive ion channels by phospholipids: a comparative study between ASICs and TRPV1A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activityRegulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasisDirect positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesisMembrane association of the PTEN tumor suppressor: electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail.Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells.Group choreography: mechanisms orchestrating the collective movement of border cellsMembrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflectionTGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucomaCasein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to AktElectrochemical coupling in the voltage-dependent phosphatase Ci-VSP.Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesCharacterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell lineA novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.A bistable model of cell polarity.Functional analysis of the protein phosphatase activity of PTENPTEN Tumor Suppressor Network in PI3K-Akt Pathway ControlPhosphatidylinositol 4-phosphate 5-kinase α negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells.
P2860
Q24297357-617659C1-11F7-4038-8D1E-A76092B77862Q24298305-A15D31F8-E0AA-4717-95C7-220A613C6308Q24300565-53E998D9-FB65-437F-A0D3-06E5571BBC20Q26797287-33BF60BD-43BE-4B3B-833B-BA488F0A91E2Q26863292-2FB889F5-4A28-4817-A4B5-8A38EE2F5E73Q27002565-1CE42595-3FAB-4485-88C8-F84A18528FFAQ27012953-147D08C0-8906-49C7-B522-601CBB81B062Q27022790-4B738DA2-7B3D-4262-B0AA-A6D715DCA364Q27024489-ED2EF558-87E5-4F5C-866A-60EEF72D5226Q27321097-68D0F59A-8849-4626-8DB7-0279A5B7EF04Q27321606-2D416268-11D3-4F38-B431-331398020F92Q27678935-8BEAAE10-B276-4BEB-8BEE-715D2DFF335CQ27852764-DF4E0DA2-69EA-404F-AE5B-D07545C676ACQ28115966-06FDB920-DD47-4660-B7C1-9ADEE7F38C27Q28267272-B6160A45-F383-45F2-92A9-EEF1D4C68CD4Q28267704-AD03C127-BF15-42FB-89A2-BD3D836F3D68Q28269344-13035B96-B55F-4868-9CFC-DD15EA83BD9AQ28299026-3DED7787-D8DB-4114-A10D-C50BD058A679Q28384095-879B814C-C448-4379-A441-282626E9E745Q28544410-3DC831E5-13DC-4E6F-A0F7-CEE967EC2EC1Q28546443-435B6639-779C-4780-A285-D1E9B9F640CCQ28586804-E832344E-74A9-4B30-999A-55480C841D42Q30156937-66E9E939-72A8-41B7-BF47-6B0C994427D1Q30392471-4604B9DD-BC7E-45C0-B8A6-1E723822347DQ30422427-375C7F54-D47B-40AE-BB25-E8C7BB78E71BQ30426736-70A64916-0653-4BDD-87E8-CC4A8717E0ADQ30583756-91458ACA-5AFA-474F-A8CC-9D78D9DE510AQ31055274-B440E90B-5AFF-4FCE-A9F7-298EA668392BQ33678064-BA692936-E58B-477D-8E15-28D8FE68EFCFQ33721897-3B161A9D-EC09-4414-8AAB-62B615305E6CQ33802097-2AD782EC-62ED-45A8-9336-ABDD7B594A05Q33854076-A2F5B0ED-D5FD-415B-9BD9-2D6BE3198375Q33909288-5D78BFEE-ED99-4386-BAFF-19882151087AQ34079578-64781ABD-4971-4CD1-A8E6-9EE55E01B917Q34099246-4EA9BFD6-4AC5-419B-A916-E2D81EB9A7BDQ34173253-F6A3AD4E-2CD4-4401-BC19-89F999CF1D14Q34181587-B850B84E-0093-4069-9C96-EB5DB47A4EACQ34194118-52814C1C-D72D-40C5-B301-993BA88A2E9CQ34202681-D5FF847A-CD60-4F3D-B2B0-E8C7D5CE98F0Q34335809-C1D711C0-42F6-48BA-980F-E898EE0A50DC
P2860
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A phosphorylation-dependent in ...... y of the tumor suppressor PTEN
@nl
A phosphorylation-dependent in ...... of the tumor suppressor PTEN.
@ast
A phosphorylation-dependent in ...... of the tumor suppressor PTEN.
@en
type
label
A phosphorylation-dependent in ...... y of the tumor suppressor PTEN
@nl
A phosphorylation-dependent in ...... of the tumor suppressor PTEN.
@ast
A phosphorylation-dependent in ...... of the tumor suppressor PTEN.
@en
prefLabel
A phosphorylation-dependent in ...... y of the tumor suppressor PTEN
@nl
A phosphorylation-dependent in ...... of the tumor suppressor PTEN.
@ast
A phosphorylation-dependent in ...... of the tumor suppressor PTEN.
@en
P2093
P2860
P3181
P356
P1476
A phosphorylation-dependent in ...... of the tumor suppressor PTEN.
@en
P2093
Francisca Vazquez
Meghdad Rahdar
Peter N Devreotes
Takanari Inoue
Tobias Meyer
P2860
P304
P3181
P356
10.1073/PNAS.0811212106
P407
P577
2008-12-29T00:00:00Z