Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
about
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionFibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein CrkJSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathwayHuman JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factorInteraction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth controlProteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytesScaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathwayRegulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathwaysMEKK4 is an effector of the embryonic TRAF4 for JNK activationActivation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinaseRaf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulationHuman mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascadesMip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulatorInterferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytesSynergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activationGadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expressionMolecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinaseActivation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domainPhosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptorsMitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-betaThe mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrateTNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase relatedAn evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKKProtein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent mannerAxin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activationIdentification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases14-3-3 proteins interact with specific MEK kinasesThe MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinasesGadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascadesIdentification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress ResponseHepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKKNeuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous systemInterleukin-18.The kinetic mechanism of the dual phosphorylation of the ATF2 transcription factor by p38 mitogen-activated protein (MAP) kinase alpha. Implications for signal/response profiles of MAP kinase pathways.
P2860
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P2860
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@ast
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@en
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@nl
type
label
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@ast
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@en
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@nl
prefLabel
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@ast
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@en
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@nl
P2093
P2860
P356
P1476
Cloning of a novel mitogen-act ...... amino terminal kinase pathway
@en
P2093
P2860
P304
P356
10.1074/JBC.272.13.8288
P407
P577
1997-03-28T00:00:00Z