Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids
about
Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically activePeptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agentsComparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptorsCharacterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptorsPharmacological properties of nociceptin/orphanin FQ-induced stimulation and inhibition of cyclic AMP formation in distinct layers of rat olfactory bulbAnti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonistNociceptin produces antinociception after spinal administration in amphibiansOpioid receptor signalling mechanisms.Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.(8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist.Analyzing the evolution of the opioid/orphanin gene family.Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosisBuprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.Activities of mixed NOP and mu-opioid receptor ligands.Development of nociceptin receptor (NOP) agonists and antagonists.Recently patented and promising ORL-1 ligands: where have we been and where are we going?A Dynamic Picture of the Early Events in Nociceptin Binding to the NOP Receptor by Metadynamics.The nociceptin pharmacophore site for opioid receptor binding derived from the NMR structure and bioactivity relationships.Nociceptin (1 - 7) antagonizes nociceptin-induced hyperalgesia in mice.Dual coupling of opioid receptor-like (ORL1) receptors to adenylyl cyclase in the different layers of the rat main olfactory bulb.The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.Direct identification of a peptide binding region in the opioid receptor-like 1 receptor by photoaffinity labeling with [Bpa(10),Tyr(14)]nociceptin.Different domains of the ORL1 and kappa-opioid receptors are involved in recognition of nociceptin and dynorphin A.Identification of a high-affinity orphanin FQ/nociceptin(1-11) binding site in mouse brain.G-protein-coupled receptor-mediated MAPK and PI3-kinase signaling is maintained in Chinese hamster ovary cells after γ-irradiation.
P2860
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P2860
Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids
description
1997 nî lūn-bûn
@nan
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Recognition and activation of ...... nociceptin analogs and opioids
@ast
Recognition and activation of ...... nociceptin analogs and opioids
@en
Recognition and activation of ...... nociceptin analogs and opioids
@nl
type
label
Recognition and activation of ...... nociceptin analogs and opioids
@ast
Recognition and activation of ...... nociceptin analogs and opioids
@en
Recognition and activation of ...... nociceptin analogs and opioids
@nl
prefLabel
Recognition and activation of ...... nociceptin analogs and opioids
@ast
Recognition and activation of ...... nociceptin analogs and opioids
@en
Recognition and activation of ...... nociceptin analogs and opioids
@nl
P2093
P1476
Recognition and activation of ...... nociceptin analogs and opioids
@en
P2093
H Mazarguil
J C Meunier
J L Butour
P304
P356
10.1016/S0014-2999(96)00919-3
P407
P50
P577
1997-02-19T00:00:00Z