Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase
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Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugsFormation of N-alkylated protoporphyrin IX in the livers of mice after diethylnitrosamine treatmentInhibition of protohaem ferro-lyase by N-substituted porphyrins. Structural requirements for the inhibitory effectLabelling in vivo and chirality of griseofulvin-derived N-alkylated protoporphyrins.Isolation of two N-monosubstituted protoporphyrins, bearing either the whole drug or a methyl group on the pyrrole nitrogen atom, from liver of mice given griseofulvin.Collision-activated dissociation studies of alkylamines formed from copper-induced dealkylation of N-alkylporphyrins.Strain and sex differences in the response of mice to drugs that induce protoporphyria: role of porphyrin biosynthesis and removal.Occurrence and biological properties of N-methyl protoporphyrin.Studies on the inhibition of ferrochelatase by N-alkylated dicarboxylic porphyrins. Steric factors involved and evidence that the inhibition is reversible.N-alkylation of the haem moiety of cytochrome P-450 caused by substituted dihydropyridines. Preferential attack of different pyrrole nitrogen atoms after induction of various cytochrome P-450 isoenzymesStructural isomerism and chirality of N-monosubstituted protoporphyrins.Inactivation of cytochrome P-450 and production of N-alkylated porphyrins caused in isolated hepatocytes by substituted dihydropyridines. Structural requirements for loss of haem and alkylation of the pyrrole nitrogen atom.Liver production of N-alkylated porphyrins caused in mice by treatment with substituted dihydropyridines. Evidence that the alkyl group on the pyrrole nitrogen atom originates from the drug.Drug-induced conversion of liver haem into modified porphyrins. Evidence for two classes of products.Inhibition of protohaem ferro-lyase in experimental porphyria. Isolation and partial characterization of a modified porphyrin inhibitor.Conversion of liver haem into N-substituted porphyrins or green pigments. Nature of the substituent at the pyrrole nitrogen atom.Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice.Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potentialAblation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury.N-Methylprotoporphyrin IX: chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine treatmentToxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.Studies in porphyria: functional evidence for a partial deficiency of ferrochelatase activity in mitogen-stimulated lymphocytes from patients with erythropoietic protoporphyria.The liver in protoporphyria.Exposure to toxic agents: the heme biosynthetic pathway and hemoproteins as indicator.Regulation by heme of synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver.Comparison of rat and human cytochrome P450 (CYP) sources of N-alkylprotoporphyrin IX. Formation after interaction with porphyrinogenic xenobiotics: studies with cDNA-expressed single CYP enzymes.Changes of Tight Junction Protein Claudins in Small Intestine and Kidney Tissues of Mice Fed a DDC Diet.Patterns of porphyrin accumulation in response to xenobiotics. Parallels between results in chick embryo and rodents.Porphyrinogenic activity and ferrochelatase-inhibitory activity of sydnones in chick embryo liver cells.Quantitative analysis of flux along the gluconeogenic, glycolytic and pentose phosphate pathways under reducing conditions in hepatocytes isolated from fed rats.Phototoxicity of protoporphyrin as related to its subcellular localization in mice livers after short-term feeding with griseofulvin.Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.Ring syntheses of the four N-methylprotoporphyrin isomers and of related N-methyl and N,N′-dimethylporphyrins
P2860
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P2860
Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase
description
1979 nî lūn-bûn
@nan
1979 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1979 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
name
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@ast
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@en
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@nl
type
label
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@ast
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@en
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@nl
prefLabel
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@ast
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@en
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@nl
P2093
P2860
P356
P1433
P1476
Studies on the mechanism of ex ...... bitor of protohaem ferro-lyase
@en
P2093
F De Matteis
T R Tephly
P2860
P356
10.1042/BJ1800241
P407
P577
1979-04-15T00:00:00Z