A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
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Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeysPharmacological characterization of the novel nociceptin/orphanin FQ receptor ligand, ZP120: in vitro and in vivo studies in miceFunctional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonistsNeuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence.Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agentsDifferential effects of nociceptin/orphanin FQ (NOP) receptor agonists in acute versus chronic pain: studies with bifunctional NOP/μ receptor agonists in the sciatic nerve ligation chronic pain model in miceThe nociceptin/orphanin FQ receptor (NOP) as a target for drug abuse medicationsCharacterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptorsNociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorderThe role of orphanin FQ/nociceptin in neuroplasticity: relationship to stress, anxiety and neuroinflammation.Activation of nociceptin/orphanin FQ peptide receptors disrupts visual but not auditory sensorimotor gating in BALB/cByJ mice: comparison to dopamine receptor agonists.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsChronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the ratDiscovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugsRole of opioid receptor like-1 receptor in modulation of endocrine, immunological, and behavioral responses to the T-cell superantigen staphylococcal enterotoxin AStress enhancement of craving during sobriety: a risk for relapse.A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory.Operant nociception in nonhuman primates.The Nociceptin Receptor as an Emerging Molecular Target for Cocaine AddictionIn vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.Pharmacological profile of nociceptin/orphanin FQ receptors.The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity.Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats.Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeysCentral injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze testPharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortexDifferential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphineStructural requirements of N-substituted spiropiperidine analogues as agonists of nociceptin/orphanin FQ receptorActivation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms.Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptorRoles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.Activities of mixed NOP and mu-opioid receptor ligands.The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability.Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys.Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.Central N/OFQ-NOP Receptor System in Pain Modulation.Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility.
P2860
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P2860
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
A synthetic agonist at the orp ...... anxiolytic profile in the rat
@nl
A synthetic agonist at the orp ...... anxiolytic profile in the rat.
@ast
A synthetic agonist at the orp ...... anxiolytic profile in the rat.
@en
type
label
A synthetic agonist at the orp ...... anxiolytic profile in the rat
@nl
A synthetic agonist at the orp ...... anxiolytic profile in the rat.
@ast
A synthetic agonist at the orp ...... anxiolytic profile in the rat.
@en
prefLabel
A synthetic agonist at the orp ...... anxiolytic profile in the rat
@nl
A synthetic agonist at the orp ...... anxiolytic profile in the rat.
@ast
A synthetic agonist at the orp ...... anxiolytic profile in the rat.
@en
P2093
P2860
P3181
P356
P1476
A synthetic agonist at the orp ...... anxiolytic profile in the rat.
@en
P2093
Dautzenberg FM
Kilpatrick G
Kolczewski S
Lundstrom K
Ouagazzal AM
P2860
P304
P3181
P356
10.1073/PNAS.090514397
P407
P577
2000-04-01T00:00:00Z